Coenzyme Q10 and its role in heart disease

Coenzyme Q(10) (CoQ(10)) deficiency has been observed in apparently healthy subjects as well as in patients with congestive heart failure, angina pectoris, coronary artery disease, cardiomyopathy, hypertension, mitral valve prolapse and after coronary revascularization. CoQ(10) bolsters the synthesis of ATP and inhibits free radical damage, hence is useful in preventing cellular damage during ischaemia-reperfusion injury. The clinical benefits are mainly due to its ability to improve energy production, antioxidant activity, and membrane stabilizing properties. Several small scale studies indicate that coenzyme Q could be useful in patients with congestive heart failure, angina pectoris, cardiomyopathy, coronary artery disease, acute myocardial infarction and in the preservation of myocardium. CoQ(10) may also decrease lipoprotein (a) and plasma insulin. CoQ(10) is normally present in the low-density lipoprotein cholesterol fraction and inhibits its oxidation indicating that it can inhibit atherosclerosis. It can also regenerate vitamin E. CoQ(10) is known for producing minor gastrointestinal discomfort and elevation in SGOT and LDH when used.