Study on the clinical significance of Argonaute2 expression in colonic carcinoma by tissue microarray

被引：1
|
作者：
Wang, Ying-Xin [1 ]
Zhang, Xiao-Yan [2 ]
Zhang, Bao-Feng [2 ]
Yang, Chang-Qing [1 ]
Gao, Heng-Jun [1 ,2 ]
机构：
[1] Tongji Univ, Tongji Inst Digest Dis, Tongji Hosp, Dept Gastroenterol, Shanghai 200065, Peoples R China
[2] Natl Engn Ctr Biochip, Shanghai 201023, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2013年 / 6卷 / 03期
关键词：
Tissue mircroarray; immunohistochemstry; colonic carcinoma; Argonaute2; INDUCED SILENCING COMPLEX; GENE AMPLIFICATION; CRYSTAL-STRUCTURE; RNA CLEAVAGE; MICRORNA; PROSTATE; CANCER; DICER; AGO2; OVEREXPRESSION;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: To study the expression levels and clinical significance of Argonaute2 (EIF2C2) on colonic carcinomas and normal tissues. Methods: Colon tissue samples from 90 cases of colonic carcinomas and 90 normal subjects were accumulated and made into a tissue microarray containing 360 dots. Expression of Argonaute2 (EIF2C2) was detected by immunohistochemical staining of the tissue microarray. Results: There was significant difference in the expression levels of Argonaute2 (EIF2C2) between colonic carcinomas and normal tissues (P<0.01). However, the expression of Argonaute2 (EIF2C2) was not related to sex, age, position, differentiation, lymphatic metastasis and clinical stage of the tumor (P>0.05). Conclusion: Abnormal expression of Argonaute2 (EIF2C2) may be correlated with colon tumorigenesis.
引用
收藏
页码：476 / 484
页数：9
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