Transition Metal Complexes of 8-Aminoquinoline-5-Substituted Uracils with Antioxidative and Cytotoxic Activities

被引：0
|
作者：
Pingaew, Ratchanok [1 ]
Worachartcheewan, Apilak [2 ,3 ]
Prachayasittikul, Veda [3 ]
Prachayasittikul, Supaluk [2 ]
Ruchirawat, Somsak [4 ,5 ]
Prachayasittikul, Virapong [3 ]
机构：
[1] Srinakharinwirot Univ, Fac Sci, Dept Chem, Bangkok 10110, Thailand
[2] Mahidol Univ, Fac Med Technol, Ctr Data Min & Biomed Informat, Bangkok 10700, Thailand
[3] Mahidol Univ, Fac Med Technol, Dept Clin Microbiol & Appl Technol, Bangkok 10700, Thailand
[4] Chulabhorn Res Inst, Bangkok 10210, Thailand
[5] Chulabhorn Grad Inst, Bangkok 10210, Thailand
来源：
LETTERS IN DRUG DESIGN & DISCOVERY | 2013年 / 10卷 / 09期
关键词：
Metal complex; 8-aminoquinoline; Uracils; Antioxidant; Cytotoxicity; ANTIMICROBIAL ACTIVITIES; COPPER-COMPLEXES; DERIVATIVES; REACTIVITY;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Metal complexes of 8-aminoquinoline (8AQ) derivatives were reported. This study presents a series of synthesized transition metal complexes of mixed ligands 8AQ-5-iodouracils (1-3) and 8AQ-5-nitrouracil (4-6) which have been investigated for their antioxidative and cytotoxic activities, as well as, powder X-ray diffraction patterns. Ni complex of 8AQ-5-nitrouracil (6) exerted significant cytotoxicity against MOLT-3 cell and superoxide scavenging activity. The results demonstrate an application of 8AQ molecule as a potential ligand for new bioactive compounds.
引用
收藏
页码：859 / 864
页数：6
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