GL-V9 reverses adriamycin resistance in hepatocellular carcinoma cells by affecting JNK2-related autophagy

被引：14

作者：

Yang Yue ^{[1
]}

Liao Yan ^{[1
]}

Gui Yan-Ping ^{[1
]}

Zhao Li ^{[1
]}

Guo Lu-Bo ^{[2
]}

机构：

[1] China Pharmaceut Univ, Sch Basic Med & Clin Pharmacol, Nanjing 211100, Peoples R China

[2] Shandong First Med Univ, Dept Pharm, Cent Hosp, Jinan 250013, Peoples R China

来源：

CHINESE JOURNAL OF NATURAL MEDICINES | 2020年 / 18卷 / 07期

基金：

中国国家自然科学基金;

关键词：

GL-V9; Drug resistance; JNK2; Autophagy; DRUG-RESISTANCE; KINASE; TUMORIGENESIS; DOXORUBICIN; APOPTOSIS;

D O I：

10.1016/S1875-5364(20)30059-5

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Adriamycin resistance in HCC seriously hinders the treatment of patients, it is necessary to investigate the mechanisms. Autophagy is involved in adriamycin resistance and JNK2 is related to autophagy. However, whether JNK2 inducing drug resistance though autophagy is unknown. GL-V9, a new synthesized flavonoid derivative, has been proved of its anti-tumor effects. The aim of the study is to explore the role of JNK2-related autophagy on adriamycin-induced drug resistance and the effects of GL-V9 on reversing adriamycin resistance. We concluded that JNK2 played an important role in drug resistance induced by adriamycin. The high expression of JNK2 activated protective autophagy in Hep G2-DOXR cells under non-stress condition, which protected cells from drug attacking. Furthermore, we found that GL-V9 reversed adriamycin resistance by blocking the JNK2-related protective autophagy in HCC.

引用

页码：491 / 499

页数：9

共 25 条

[1] Poly(ADP-ribose) polymerase family member 14 (PARP14) is a novel effector of the JNK2-dependent pro-survival signal in multiple myeloma
Barbarulo, A.
Iansante, V.
Chaidos, A.
Naresh, K.
Rahemtulla, A.
Franzoso, G.
Karadimitris, A.
Haskard, D. O.
Papa, S.
Bubici, C.
[J]. ONCOGENE, 2013, 32 (36) : 4231 - 4242
[2] Hepatocellular carcinoma cells surviving doxorubicin treatment exhibit increased migratory potential and resistance to doxorubicin re-treatment in vitro
Buschauer, Sebastian
Koch, Andreas
Wiggermann, Philipp
Mueller, Martina
Hellerbrand, Claus
[J]. ONCOLOGY LETTERS, 2018, 15 (04) : 4635 - 4640
[3] Mammalian MAP kinase signalling cascades
Chang, LF
Karin, M
[J]. NATURE, 2001, 410 (6824) : 37 - 40
[4] Chen NY, 2001, CANCER RES, V61, P3908
[5] Rapid Identification of Genetic Modifications in Bacillus anthracis Using Whole Genome Draft Sequences Generated by 454 Pyrosequencing
Chen, Peter E.
Willner, Kristin M.
Butani, Amy
Dorsey, Shakia
George, Matroner
Stewart, Andrew
Lentz, Shannon M.
Cook, Christopher E.
Akmal, Arya
Price, Lance B.
Keim, Paul S.
Mateczun, Alfred
Brahmbhatt, Trupti N.
Bishop-Lilly, Kimberly A.
Zwick, Michael E.
Read, Timothy D.
Sozhamannan, Shanmuga
[J]. PLOS ONE, 2010, 5 (08):
[6] A Review of Hepatocellular Carcinoma in Elderly Patients Focused on Management and Outcomes
Cho, Eunae
Cho, Hyun A.
Jun, Chung Hwan
Kim, Hee Joon
Cho, Sung Bum
Choi, Sung Kyu
[J]. IN VIVO, 2019, 33 (05): : 1411 - 1420
[7] BCL2L11/Bim as a dual-agent regulating autophagy and apoptosis in drug resistance
Dai, Yun
Grant, Steven
[J]. AUTOPHAGY, 2015, 11 (02) : 416 - 418
[8] Signal transduction by the JNK group of MAP kinases
Davis, RJ
[J]. CELL, 2000, 103 (02) : 239 - 252
[9] BMP4 promotes hepatocellular carcinoma proliferation by autophagy activation through JNK1-mediated Bcl-2 phosphorylation
Deng, Ganlu
Zeng, Shan
Qu, Yanling
Luo, Qingqing
Guo, Cao
Yin, Ling
Han, Ying
Li, Yiyi
Cai, Changjing
Fu, Yaojie
Shen, Hong
[J]. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2018, 37
[10] Flavonoid GL-V9 induces apoptosis and inhibits glycolysis of breast cancer via disrupting GSK-3β-modulated mitochondrial binding of HKII
Guo, Yongjian
Wei, Libin
Zhou, Yuxin
Lu, Na
Tang, Xiaoqing
Li, Zhiyu
Wang, Xiaotang
[J]. FREE RADICAL BIOLOGY AND MEDICINE, 2020, 146 : 119 - 129

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