Cardioprotection by Guanxin II in rats with acute myocardial infarction is related to its three compounds

被引：35
作者：
Huang, Xi [1 ,2 ]
Qin, Feng [1 ,2 ]
Zhang, Hong-Min [3 ,4 ]
Xiao, Hong-Bin [5 ]
Wang, Long-Xin [5 ]
Zhang, Xue-Ya [6 ]
Ren, Ping [1 ,2 ]
机构：
[1] Cent S Univ, Inst Integrated Tradit Med & Western Med, Xiangya Hosp, Changsha 410008, Hunan, Peoples R China
[2] Cent S Univ, Lab Ethnopharmacol, Changsha 410008, Hunan, Peoples R China
[3] Henan Prov Peoples Hosp, Henan Inst Ophthalmol, Zhengzhou 450003, Peoples R China
[4] Henan Prov Peoples Hosp, Dept Ophthalmol, Zhengzhou 450003, Peoples R China
[5] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116012, Peoples R China
[6] Sichuan Univ, W China Hosp, Lab Ethnopharmacol, Chengdu 610041, Peoples R China
来源：
JOURNAL OF ETHNOPHARMACOLOGY | 2009年 / 121卷 / 02期
关键词：
Traditional Chinese medicine; Absorbed bioactive compounds; Myocardial infarction; Guanxin II; Apoptosis; ISCHEMIA-REPERFUSION INJURY; XIN-ER-HAO; SALVIA-MILTIORRHIZA; HEART; PAEONIFLORIN; REMEDIES; THERAPY; TARGET; AREA;
D O I：
10.1016/j.jep.2008.10.029
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Aim: We tested the hypothesis that cardioprotection afforded by traditional Chinese Guanxin II (GXII) formula is related to absorbed bioactive compounds (ABCs). Methods: Sprague-Dawley rats with acute myocardial infarction (AMI) were induced by coronary occlusion. ABCs including ferulic acid (F), hydroxyl safflor yellow A (A), tanshinol (T), protocatechualdehyde (P) and paeoniflorin (E) were measured in blood after oral GXII. The effects of GXII and FATPE, alone and in combination, and of some components of FATPE on infarct size. myocardial apoptosis and caspase-3 activity were determined. Myocardial blood flow (MBF) in AMI rat was detected 2 In after oral CXII and FAT. Results: FATPE was found in rat blood. FAT was similar to FATPE and GXII in decreasing infarct size, myocardial apoptosis and caspase-3 activity of AMI. Both FAT and GXII were similar in increasing of MBF. Conclusion: GXII and FAT protect the heart from ischemic injury by increasing MBF, and decrease infarct size by inhibiting myocardial apoptosis and caspase-3 activity. These findings provide a potential cardio-protective cocktail. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：68 / 73
页数：6
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