N,N,N-Trimethyl chitosan: An advanced polymer with myriad of opportunities in nanomedicine

被引：126

作者：

Kulkarni, Abhijeet D. ^{[1
]}

Patel, Harun M. ^{[2
]}

Surana, Sanjay J. ^{[3
]}

Vanjari, Yogesh H. ^{[4
]}

Belgamwar, Veena S. ^{[5
]}

Pardeshi, Chandrakantsing V. ^{[1
]}

机构：

[1] RC Patel Inst Pharmaceut Educ & Res, Dept Pharmaceut, Ind Pharm Lab, Shirpur, Maharashtra, India

[2] RC Patel Inst Pharmaceut Educ & Res, Dept Pharmaceut Chem, Div Comp Aided Drug Design, Shirpur, Maharashtra, India

[3] RC Patel Inst Pharmaceut Educ & Res, Dept Pharmacognosy, Shirpur, Maharashtra, India

[4] NIPER, Dept Pharmaceut Chem, Med Chem Lab, Hyderabad, Karnataka, India

[5] RTM Nagpur Univ, Dept Pharmaceut Sci, Nagpur, Maharashtra, India

来源：

CARBOHYDRATE POLYMERS | 2017年 / 157卷

关键词：

Chitosan; Trimethyl chitosan; Mucoadhesion; Nanomedicine; Tissue engineering; Nasal vaccine; N-TRIMETHYL CHITOSAN; PENETRATION ENHANCEMENT PROPERTIES; CACO-2 CELL MONOLAYERS; EXCISED RAT JEJUNUM; IN-VITRO EVALUATION; TNF-ALPHA SIRNA; ORAL DELIVERY; MOLECULAR-WEIGHT; NASAL VACCINATION; TMC NANOPARTICLES;

D O I：

10.1016/j.carbpol.2016.10.041

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

N,N,N-trimethyl chitosan (TMC), a quaternized hydrophilic derivative of chitosan (CHT), outperformed the well-known solubility issues raised by CHT. The excellent properties offered by TMC provide it a significant edge for nanoparticle (NP) formation over other nanocarrier materials. Recently, TMC NPs have been applied to various fields like pharmaceutical, biomedical, biomaterials, and biotechnological field. The aim of this review is, therefore, to bring the TMC into the limelight so as to appraise it as an attractive functional polymer for nanomedicine applications which is facing oversight, at present, by regulatory agencies and manufacturers. The versatility of surface-tailoring, the capability of further chemical modifications, and the feasibility of ligand-conjugations in TMC polymer will further assist the scientists for reaching new dimensions in the nano-assembly of novel structures based on TMC. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：875 / 902

页数：28

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