Development and characterization of novel biomimetic composite scaffolds based on bioglass-collagen-hyaluronic acid-phosphatidylserine for tissue engineering applications

被引：37
作者：
Wang, YJ
Yang, CR [1 ]
Chen, XF
Zhao, NR
机构：
[1] S China Univ Technol, Minist Educ, Coll Mat Sci & Engn, Guangzhou 510640, Guangdong, Peoples R China
[2] S China Univ Technol, Minist Educ, Key lab Specially Funct Mat & Adv Mfg Technol, Guangzhou 510640, Guangdong, Peoples R China
来源：
MACROMOLECULAR MATERIALS AND ENGINEERING | 2006年 / 291卷 / 03期
关键词：
biomimetic; composites; scaffold; tissue engineering;
D O I：
10.1002/mame.200500381
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Biomimetic scaffolds are appealing products for the repair of bone defects using tissue engineering strategies. The present study prepared novel biomimetic composite scaffolds with similar composite to natural bone using bioactive glass, collagen, hyaluronic acid, and phosphatidylserine. The microstructure, swelling ratio, biodegradability, and biomineralization characteristic of the composite scaffolds with and without hyaluronic acid and phosphatidylserine were compared and analyzed by SEM/EDAX, XRD, and FTIR techniques and in vitro test, and the properties can be influenced by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)/N-hydroxysuccinimide (NHS) crosslinking. The optimized properties of the crosslinked composite scaffolds observed in this study show the possibility of their use of bioactive and bioresorbable scaffolds in bone tissue engineenng.
引用
收藏
页码：254 / 262
页数：9
相关论文
共 26 条
  • [1] ANDERSON HC, 1978, METAB BONE DIS RELAT, V1, P83
  • [2] ROLE OF CALCIUM-PHOSPHOLIPID-PHOSPHATE COMPLEXES IN TISSUE MINERALIZATION
    BOSKEY, AL
    [J]. METABOLIC BONE DISEASE & RELATED RESEARCH, 1978, 1 (02): : 137 - 142
  • [3] BOSKEY AL, 1977, P SOC EXP BIOL MED, V157, P588
  • [4] Influence of different crosslinking treatments on the physical properties of collagen membranes
    Charulatha, V
    Rajaram, A
    [J]. BIOMATERIALS, 2003, 24 (05) : 759 - 767
  • [5] Mechanical characterization of collagen fibers and scaffolds for tissue engineering
    Gentleman, E
    Lay, AN
    Dickerson, DA
    Nauman, EA
    Livesay, GA
    Dee, KC
    [J]. BIOMATERIALS, 2003, 24 (21) : 3805 - 3813
  • [6] MECHANISM OF CALCIFICATION - ROLE OF COLLAGEN FIBRILS AND COLLAGEN PHOSPHOPROTEIN COMPLEXES INVITRO AND INVIVO
    GLIMCHER, MJ
    [J]. ANATOMICAL RECORD, 1989, 224 (02): : 139 - 153
  • [7] CONFOCAL LASER-SCANNING MICROSCOPY (CLSM) FOR THE STUDY OF COLLAGEN SPONGE MICROSTRUCTURE
    HANTHAMRONGWIT, M
    GRANT, MH
    WILKINSON, R
    [J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1994, 28 (02): : 213 - 216
  • [8] Hench LL, 1998, J AM CERAM SOC, V81, P1705
  • [9] Fabrication of porous gelatin scaffolds for tissue engineering
    Kang, HW
    Tabata, Y
    Ikada, Y
    [J]. BIOMATERIALS, 1999, 20 (14) : 1339 - 1344
  • [10] Bioabsorbable scaffolds for guided bone regeneration and generation
    Kellomäki, M
    Niiranen, H
    Puumanen, K
    Ashammakhi, N
    Waris, T
    Törmälä, P
    [J]. BIOMATERIALS, 2000, 21 (24) : 2495 - 2505
123