Recurrent Streptococcus agalactiae Toxic Shock Syndrome Triggered by a Tumor Necrosis Factor-α Inhibitor

被引：5

作者：

Yoshida, Masataka ^{[1
,2
]}

Takazono, Takahiro ^{[1
,2
]}

Tashiro, Masato ^{[2
]}

Saijo, Tomomi ^{[1
]}

Morinaga, Yoshitomo ^{[3
]}

Yamamoto, Kazuko ^{[1
]}

Nakamura, Shigeki ^{[1
]}

Imamura, Yoshifumi ^{[1
]}

Miyazaki, Taiga ^{[1
,2
]}

Sawai, Toyomitsu ^{[4
]}

Nishino, Tomoya ^{[1
]}

Izumikawa, Koichi ^{[2
]}

Yanagihara, Katsunori ^{[3
]}

Mukae, Hiroshi ^{[1
]}

Kohno, Shigeru ^{[1
]}

机构：

[1] Nagasaki Univ Hosp, Dept Internal Med 2, Nagasaki, Nagasaki Prefec, Japan

[2] Nagasaki Univ, Grad Sch Biomed Sci, Dept Infect Dis, Nagasaki, Nagasaki Prefec, Japan

[3] Nagasaki Univ Hosp, Dept Lab Med, Nagasaki, Nagasaki Prefec, Japan

[4] Nagasaki Municipal Hosp, Dept Internal Med, Nagasaki, Japan

来源：

INTERNAL MEDICINE | 2016年 / 55卷 / 21期

关键词：

streptococcal toxic shock syndrome; recurrent; tumor necrosis factor-alpha inhibitor; infliximab; Streptococcus agalactiae; GROUP-B-STREPTOCOCCUS; INVASIVE GROUP-A; NECROTIZING FASCIITIS; RHEUMATOID-ARTHRITIS; NONPREGNANT ADULTS; PSORIASIS; SURVEILLANCE; ETANERCEPT; PATIENT; JAPAN;

D O I：

10.2169/internalmedicine.55.6787

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Streptococcal toxic shock syndrome caused by group B streptococcus (GBS) is a rare, but lethal disease. We experienced a 45-year-old woman with pustular psoriasis who developed toxic shock-like syndrome during infliximab treatment. Surprisingly, similar episodes recurred three times in one year with restarting of infliximab treatments. In the third episode, GBS were detected in blood, urine, and vaginal secretion cultures. These episodes of shock syndrome were possibly due to GBS. To the best of our knowledge, this is the first case report of recurrent streptococcal toxic shock syndrome possibly caused by GBS which was induced by anti-TNF-alpha inhibitor therapy. The restarting of biological agents in patients with a history of toxic shock syndrome should therefore be avoided as much as possible.

引用

页码：3211 / 3214

页数：4