Clostridium difficile Infection in Pediatric Acute Myeloid Leukemia: From The Canadian Infections in Acute Myeloid Leukemia Research Group

被引：18

作者：

Price, Victoria

Portwine, Carol ^{[1
]}

Zelcer, Shayna ^{[2
]}

Ethier, Marie-Chantal ^{[3
]}

Gillmeister, Biljana ^{[3
]}

Silva, Mariana ^{[4
]}

Schindera, Christina ^{[5
]}

Yanofsky, Rochelle ^{[6
]}

Mitchell, David ^{[7
]}

Johnston, Donna L. ^{[8
]}

Lewis, Victor ^{[9
]}

Dix, David ^{[10
]}

Cellot, Sonia

Michon, Bruno ^{[11
]}

Bowes, Lynette

Stobart, Kent ^{[12
]}

Brossard, Josee ^{[13
]}

Beyene, Joseph ^{[3
,14
]}

Sung, Lillian ^{[3
,5
]}

机构：

[1] Hamilton Hlth Sci, McMaster Childrens Hosp, Hamilton, ON, Canada

[2] London Hlth Sci, Hematol Oncol, London, ON, Canada

[3] Hosp Sick Children, Toronto, ON M5G 1X8, Canada

[4] Canc Ctr Southeastern Ontario, Kingston, ON, Canada

[5] Hosp Sick Children, Div Haematol Oncol, Toronto, ON M5G 1X8, Canada

[6] CancerCare Manitoba, Hematol Oncol, Winnipeg, MB, Canada

[7] Montreal Childrens Hosp, Montreal, PQ, Canada

[8] Childrens Hosp Eastern Ontario, Ottawa, ON, Canada

[9] Alberta Childrens Prov Gen Hosp, Hematol Oncol Transplant Program, Calgary, AB, Canada

[10] British Columbia Childrens Hosp, Vancouver, BC, Canada

[11] Hosp Univ Quebec, Pediat Hematol Oncol Ctr, Quebec City, PQ, Canada

[12] Univ Alberta Hosp, Stollery Childrens Hosp, Edmonton, AB, Canada

[13] CHU Sherbrooke, Sherbrooke, PQ, Canada

[14] McMaster Univ, Dept Clin Epidemiol & Biostat, Populat Genom Program, Hamilton, ON L8S 4L8, Canada

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2013年 / 32卷 / 06期

基金：

加拿大健康研究院;

关键词：

Clostridium difficile; infection; pediatrics; acute myeloid leukemia; Canada; RISK-FACTORS; DIARRHEA; CHILDREN; EPIDEMIOLOGY; COLITIS; UPDATE;

D O I：

10.1097/INF.0b013e31828690a4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: The prevalence and severity of Clostridium difficile infection (CDI) has increased over time in adult patients, but little is known about CDI in pediatric cancer. The primary objectives were to describe the incidence and characteristics of CDI in children with de novo acute myeloid leukemia (AML). The secondary objective was to describe factors associated with CDI. Method: We performed a multicenter, retrospective cohort study of children with de novo AML and evaluated CDI. Recurrence, sepsis and infection-related death were examined. Factors associated with CDI were also evaluated. Results: Forty-three CDI occurred in 37 of 341 (10.9%) patients during 42 of 1277 (3.3%) courses of chemotherapy. There were 6 children with multiple episodes of CDI. Three infections were associated with sepsis, and no children died of CDI. Only 2 children had an associated enterocolitis. Both days of broad-spectrum antibiotics (odds ratio 1.03, 95% confidence interval: 1.01 to 1.06; P = 0.003) and at least 1 microbiologically documented sterile site infection (odds ratio 10.81, 95% confidence interval: 5.88 to 19.89; P < 0.0001) were independently associated with CDI. Conclusions: CDI occurred in 11% of children receiving intensive chemotherapy for AML, and outcomes were not severe. CDI is not a prominent issue in pediatric AML in terms of prevalence, incidence or associated outcomes.

引用

页码：610 / 613

页数：4

共 31 条

[1] CLOSTRIDIUM-DIFFICILE INFECTION ASSOCIATED WITH ANTINEOPLASTIC CHEMOTHERAPY - A REVIEW [J].