Bilateral Retiform Sertoli-Leydig Cell Tumour in a Bitch. Alpha-Inhibin and Epithelial Membrane Antigen as Useful Tools for Differential Diagnosis

被引：6

作者：

Gomez-Laguna, J. ^{[1
]}

Millan, Y. ^{[1
]}

Reymundo, C. ^{[2
]}

Domingo, V. ^{[3
]}

de las Mulas, J. Martin ^{[1
]}

机构：

[1] Fac Vet, Dept Anat & Anat Patol Comparadas, Edificio Sanidad Anim, Granada, Spain

[2] Univ Cordoba, Fac Med, Dept Especialidades Med Quirurg, Granada, Spain

[3] Clin Vet Recuerda, Granada, Spain

来源：

JOURNAL OF COMPARATIVE PATHOLOGY | 2008年 / 139卷 / 2-3期

关键词：

bitch; immunohistochemistry; ovary; Sertoli-Leydig cell tumour;

D O I：

10.1016/j.jcpa.2008.05.006

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Sertoli-Leydig cell tumours with a retiform pattern similar to the pattern of the rete testis are a subtype of sex cord-stromal tumours recognized in the human WHO histological classification of ovarian tumours but not ill the equivalent classification for domestic animals. The morphology of the tumour may be confused with that of the more common ovarian epithelial tumour. The gross, microscopical and immunohistochemical features of a canine retiform Sertoli-Leydig cell tumour and its comparison with the human counterpart are presented in this report. Both ovaries were enlarged and cystic. Microscopically, the tumour was cystic with tubulopapillary growth characterized by narrow, elongated branching tubules. Immunohistochemically, the tumour cells expressed alpha-inhibin, while epithelial membrane antigen was not detected, indicating a sex cord-stromal origin of the tumour. Additionally, the tumour cells expressed cytokeratin and vimentin in addition to oestrogen receptor alpha and progesterone receptor. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：137 / 140

页数：4