Machilusmarin, a new neuroprotective isocoumarin dimer from the stems of Machilus ichangensis Rehd. et Wils.

被引：10

作者：

Cheng, Fan ^{[1
]}

Deng, Zhangshuang ^{[2
]}

Guo, Zhiyong ^{[2
]}

Chen, Jianfeng ^{[2
]}

Zou, Kun ^{[1
,2
]}

机构：

[1] Beijing Forestry Univ, Coll Biol Sci & Biotechnol, Beijing 100083, Peoples R China

[2] China Three Gorges Univ, Coll Chem & Life Sci, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2013年 / 27卷 / 17期

关键词：

Machilus ichangensis Rehd. et Wils; isocoumarin dimmer; neuroprotective activity;

D O I：

10.1080/14786419.2012.733392

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new isocoumarin dimer, Machilusmarin (1), was isolated from the stem of Machilus ichangensis Rehd. et Wils., together with two known coumarins, scopoletin (2) and isoscopoletin (3). The structure of Machilusmarin (1) was elucidated by HRMS and NMR spectrums. Machilusmarin (1) showed significant neuroprotective activity against SH-SY5Y human neuroblastoma cells apoptosis induced by hydrogen peroxide at concentrations ranging from 0.625 to 10.0 mu gmL(-1).

引用

页码：1542 / 1547

页数：6

共 10 条

[1] Steryl epoxide, secobutanolide and butanolides from the stem wood of Machilus zuihoensis [J].

Cheng, MJ ;

Tsai, IL ;

Lee, SJ ;

Jayaprakasam, B ;

Chen, IS .

PHYTOCHEMISTRY, 2005, 66 (10) :1180-1185

[2] Chemical Constituents of the Bark of Machilus wangchiana and Their Biological Activities [J].

Cheng, Wei ;

Zhu, Chenggen ;

Xu, Wendong ;

Fan, Xiaona ;

Yang, Yongchun ;

Li, Yan ;

Chen, Xiaoguang ;

Wang, Wenjie ;

Shi, Jiangong .

JOURNAL OF NATURAL PRODUCTS, 2009, 72 (12) :2145-2152

[3] High molecular weight plant polyphenolics (tannins) as biological antioxidants [J].

Hagerman, AE ;

Riedl, KM ;

Jones, GA ;

Sovik, KN ;

Ritchard, NT ;

Hartzfeld, PW ;

Riechel, TL .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1998, 46 (05) :1887-1892

[4]

Jiangsu New Medical College, 1977, Dictionary of Traditional Chinese Medicine

[5] Acylated flavonol monorhamnosides, α-glucosidase inhibitors, from Machilus philippinensis [J].

Lee, Shoei-Sheng ;

Lin, Hsiao-Ching ;

Chen, Chien-Kuang .

PHYTOCHEMISTRY, 2008, 69 (12) :2347-2353

[6] Two novel glycosidic triterpene alkaloids from the stem barks of Machilus yaoshansis [J].

Liu, Ming-Tao ;

Lin, Sheng ;

Wang, Ying-Hong ;

He, Wen-Yi ;

Li, Shuai ;

Wang, Su-Juan ;

Yang, Yong-Chun ;

Shi, Jian-Gong .

ORGANIC LETTERS, 2007, 9 (01) :129-132

[7] CRYSTAL AND MOLECULAR-STRUCTURE OF TRANS-BIPHTHALYL, C16H8O4 - REACTION OF SUBSTITUTED PHTHALIC ANHYDRIDES WITH TRIALKYL PHOSPHITES [J].

RAMIREZ, F ;

RICCI, JS ;

TSUBOI, H ;

MARECEK, JF ;

YAMANAKA, H .

JOURNAL OF ORGANIC CHEMISTRY, 1976, 41 (24) :3909-3914

[8] THE STRUCTURE OF CASTANAGUYONE A BIISOCOUMARIN PLANT PRODUCT [J].

SNYDER, J ;

NAKANISHI, K .

TETRAHEDRON LETTERS, 1981, 22 (50) :5015-5018

[9] PHENOLIC GLUCOSIDES FROM OLEA-EUROPAEA SUBSP AFRICANA [J].

TSUKAMOTO, H ;

HISADA, S ;

NISHIBE, S ;

ROUX, DG .

PHYTOCHEMISTRY, 1984, 23 (12) :2839-2841

[10]

Yoon JeongSeon Yoon JeongSeon, 2008, Natural Product Sciences, V14, P167

← 1 →