The multifaceted functions of sirtuins in cancer

被引：387

作者：

Chalkiadaki, Angeliki ^{[1
]}

Guarente, Leonard ^{[1
,2
]}

机构：

[1] MIT, Dept Biol, Paul F Glenn Ctr Sci Aging, Cambridge, MA 02139 USA

[2] MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

来源：

NATURE REVIEWS CANCER | 2015年 / 15卷 / 10期

基金：

美国国家卫生研究院;

关键词：

HYPOXIA-INDUCIBLE FACTOR; HISTONE DEACETYLASE SIRT6; TO-MESENCHYMAL TRANSITION; TUMOR-SUPPRESSOR GENE; FATTY-ACID OXIDATION; DNA-DAMAGE RESPONSE; CALORIE RESTRICTION; CELL-SURVIVAL; C-MYC; BREAST-CANCER;

D O I：

10.1038/nrc3985

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The sirtuins (SIRTs; of which there are seven in mammals) are NAD(+)-dependent enzymes that regulate a large number of cellular pathways and forestall the progression of ageing and age-associated diseases. In recent years, the role of sirtuins in cancer biology has become increasingly apparent, and growing evidence demonstrates that sirtuins regulate many processes that go awry in cancer cells, such as cellular metabolism, the regulation of chromatin structure and the maintenance of genomic stability. In this article, we review recent advances in our understanding of how sirtuins affect cancer metabolism, DNA repair and the tumour microenvironment and how activating or inhibiting sirtuins may be important in preventing or treating cancer.

引用

页码：608 / 624

页数：17

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