Engineered Microneedle Patches for Controlled Release of Active Compounds: Recent Advances in Release Profile Tuning

被引：72

作者：

Jamaledin, Rezvan ^{[1
,2
]}

Makvandi, Pooyan ^{[3
]}

Yiu, Cynthia K. Y. ^{[4
]}

Agarwal, Tarun ^{[5
]}

Vecchione, Raffaele ^{[2
]}

Sun, Wujin ^{[6
]}

Maiti, Tapas Kumar ^{[5
]}

Tay, Franklin R. ^{[7
]}

Netti, Paolo Antonio ^{[2
]}

机构：

[1] Univ Naples Federico II, Dept Chem Mat & Ind Prod Engn, I-80125 Naples, Italy

[2] Italian Inst Technol, Ctr Adv Biomat Hlth Care Iit CRIB, I-80125 Naples, Italy

[3] Ist Italiano Tecnol IIT, Ctr MicrobioRobot, Viale R Piaggio 34, I-56025 Pisa, Italy

[4] Univ Hong Kong, Paediat Dent & Orthodont, Fac Dent, Prince Philip Dent Hosp, Hong Kong, Peoples R China

[5] Indian Inst Technol, Dept Biotechnol, Kharagpur 721302, W Bengal, India

[6] Univ Calif Los Angeles, Dept Bioengn, Ctr Minimally Invas Therapeut, Los Angeles, CA 90095 USA

[7] Augusta Univ, Grad Sch, Augusta, GA 30912 USA

来源：

ADVANCED THERAPEUTICS | 2020年 / 3卷 / 12期

关键词：

controlled release; drug delivery efficacy; microneedles; drug release mechanisms; responsive microneedles; transdermal patches; SILK FIBROIN MICRONEEDLES; TRANSDERMAL DRUG-DELIVERY; DISSOLVING MICRONEEDLES; SEPARABLE MICRONEEDLES; POLYMERIC MICRONEEDLES; CHITOSAN MICRONEEDLES; CANCER-IMMUNOTHERAPY; INTRADERMAL DELIVERY; HOLLOW MICRONEEDLES; SENSITIVE VESICLES;

D O I：

10.1002/adtp.202000171

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Transdermal microneedle patches have attracted significant attention in the medical arena over the last decade as alternatives to traditional drug delivery methods. Microneedle patches are capable of delivering their payloads using burst- and sustained-release mechanisms, or in response to internal/external triggers, to optimize their therapeutic potency. Herein, drug release mechanisms and profiles are reviewed, along with the impact of the cargo release on cytotoxicity and delivery efficacy. The potential applications of microneedles in transdermal treatment, from prophylaxis to therapeutics, are also highlighted.

引用

页数：27

共 159 条

[41] Utility of lidocaine as a topical analgesic and improvements in patch delivery systems [J].