The Activity of Class I-IV Alcohol Dehydrogenase Isoenzymes and Aldehyde Dehydrogenase in Bladder Cancer Cells

被引：4
作者：
Orywal, Karolina [1 ]
Jelski, Wojciech [1 ]
Werel, Tadeusz [2 ]
Szmitkowski, Maciej [1 ]
机构：
[1] Med Univ, Dept Biochem Diagnost, Bialystok, Podlaskie, Poland
[2] Med Univ, Dept Urol, Bialystok, Podlaskie, Poland
来源：
CANCER INVESTIGATION | 2018年 / 36卷 / 01期
关键词：
Alcohol dehydrogenase isoenzymes; Aldehyde dehydrogenase; Bladder cancer; Carcinogenesis; Fluorometric method; CLASS-III; METABOLISM; ISOZYMES; RISK; ADH3;
D O I：
10.1080/07357907.2017.1422511
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Objectives: The aim of this study was to determine the differences in the activity of Alcohol Dehydrogenase (ADH) isoenzymes and Aldehyde Dehydrogenase (ALDH) in normal and cancerous bladder cells. Methods: Class III, IV of ADH and total ADH activity were measured by the photometric method and class I, II ADH and ALDH activity by the fluorometric method. Results: Significantly higher total activity of ADH was found in both, low-grade and high-grade bladder cancer, in comparison to healthy tissues. Conclusion: The increased activity of total ADH in bladder cancer cells may be the cause of metabolic disorders in cancer cells, which may intensify carcinogenesis.
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收藏
页码：66 / 72
页数：7
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