Severe Infection of Pseudomonas aeruginosa during Eculizumab Therapy for Paroxysmal Nocturnal Hemoglobinuria

被引：13

作者：

Kawakami, Toru ^{[1
]}

Nakazawa, Hideyuki ^{[1
]}

Kurasawa, Yukifumi ^{[2
]}

Sakai, Hitoshi ^{[1
]}

Nishina, Sayaka ^{[1
]}

Senoo, Noriko ^{[1
]}

Senoo, Yasushi ^{[1
]}

Ishida, Fumihiro ^{[1
,3
]}

机构：

[1] Shinshu Univ, Sch Med, Dept Internal Med, Div Hematol, Matsumoto, Nagano, Japan

[2] Shinshu Univ, Sch Med, Div Nephrol, Dept Internal Med, Matsumoto, Nagano, Japan

[3] Shinshu Univ, Sch Med, Dept Biomed Lab Sci, Matsumoto, Nagano, Japan

来源：

INTERNAL MEDICINE | 2018年 / 57卷 / 01期

关键词：

eculizumab; Pseudomonas aeruginosa; paroxysmal nocturnal hemoglobinuria; anti-complement therapy;

D O I：

10.2169/internalmedicine.9151-17

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Eculizumab is the complement inhibitor administered to ameliorate intravascular hemolysis in paroxysmal nocturnal hemoglobinuria. Whether or not the inhibitory mechanism may also increase the susceptibility to non-Neisserial infection is unclear. A 73-year old woman presented with bacteremia, cholecystitis and liver abscess with Pseudomonas aeruginosa. Although she had been neutropenic for 21 years, she had no history of severe infection before eculizumab had been administered. The infection with P. aeruginosa was successfully controlled with antibiotics, granulocyte colony-stimulating factor and cholecystectomy. The present case might be representative of less common bacterial infections than Neisseria spp. among patients treated with eculizumab.

引用

页码：127 / 130

页数：4

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