A randomized multicenter study comparing seawater washes and carmellose artificial tears eyedrops in the treatment of dry eye syndrome

被引:10
作者
Diaz-Llopis, Manuel [1 ,2 ,3 ,4 ,5 ]
Dolores Pinazo-Duran, Maria [2 ,3 ,6 ,7 ,8 ,9 ]
Diaz-Guinon, Loreto [5 ]
Rahhal-Ortuno, Miriam [10 ]
Perez-Ramos, Mercedes [8 ,9 ]
Bosch, Rosabel [8 ,9 ]
Gallego-Pinazo, Roberto [11 ,12 ]
Dolz-Marco, Rosa [11 ,12 ]
Diaz-Guinon, Teresa [5 ]
Diaz, Maria [1 ,5 ]
Javier Romero, Francisco [13 ]
Cisneros, Angel [10 ]
机构
[1] Univ Valencia, Ave Blasco Ibanez 13, Valencia 46010, Spain
[2] Univ Valencia, Fac Med, Ophthalmol Unit, Valencia, Spain
[3] Univ Valencia, Fac Med, Mol Ophthalmol Unit, Valencia, Spain
[4] Valencian Autonomous Govt, Valencian Reg Hlth Minist, Conselleria Sanitat, Valencia, Spain
[5] IOVA Valencia Ophthalmol Inst, Valencia, Spain
[6] Hosp Univ Doctor Peset, Valencia, Spain
[7] FISABIO, Santiago Grisolia Eye Res Lab, Valencia, Spain
[8] Specialised Med Ctr Alboraya, Valencia, Spain
[9] Specialised Med Ctr Monteolivete, Valencia, Spain
[10] La Fe Hosp, Dept Ophthalmol, Valencia, Spain
[11] IMED Hosp, Valencia, Spain
[12] Oftalvist Clin, Valencia, Spain
[13] European Univ Valencia, Valencia, Spain
关键词
dry eye syndrome; isotonic seawater; artificial tears; carmellose; IL-1; beta; IL-6; quality of life; QUALITY-OF-LIFE; SKIN; INFLAMMATION; DERMATITIS; PREVENTION; SYMPTOMS; RHINITIS;
D O I
10.2147/OPTH.S185409
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose: To investigate the safety and efficacy of sterile isotonic seawater washes vs standard treatment with carmellose artificial tears in dry eye syndrome (DES). Patients and methods: This is a randomized multicenter prospective study with 12 weeks of follow-up. A group of patients with DES (N= 60) were treated with seawater spray (Quinton (R)) five times daily, and another similar group (N= 60) were treated with carmellose artificial tears eyedrops (Viscofresh (R) 0.5%) five times a day. The parameters studied and measured were as follows: Ocular Surface Disease Index questionnaire score, Schirmer I test (without anesthesia) score, tear osmolarity (TearLab (R)), tear breakup time, tear meniscus height (meniscography OCT), fluorescein corneal staining score (National Eye Institute scale), lissamine green conjunctival staining score, and levels of IL-1 beta and IL-6 in tears (Luminex (R) 200). Results: In the group treated with seawater, symptoms decreased by 68%, and the decrease was 26% statistically superior to the group treated with carmellose artificial tears eyedrops (P<0.001). Levels of IL-1 beta and IL-6 in tears significantly decreased in the seawater group compared to the carmellose artificial tears group (19%/17% vs 52%/51%) (P<0.001). There were no statistically significant differences in the other measured parameters. There were no cases of poor tolerance or side effects. Conclusion: Administration of seawater is more effective than treatment with carmellose artificial tears in reducing symptoms and pro-inflammatory molecules (IL-1 beta and IL-6) in tears of patients with DES.
引用
收藏
页码:483 / 490
页数:8
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