Diagnosis and management of neuromyelitis optica spectrum disorders - An update

被引：97

作者：

Bruscolini, Alice ^{[1
]}

Sacchetti, Marta ^{[1
]}

La Cava, Maurizio ^{[1
]}

Gharbiya, Magda ^{[1
]}

Ralli, Massimo ^{[2
]}

Lambiase, Alessandro ^{[1
]}

De Virgilio, Armando ^{[3
]}

Greco, Antonio ^{[1
]}

机构：

[1] Sapienza Univ Rome, Dept Sense Organs, Viale Policlin 155, I-00161 Rome, Italy

[2] Sapienza Univ Rome, Dept Oral & Maxillofacial Sci, Viale Policlin 155, I-00161 Rome, Italy

[3] Humanitas Clin & Res Ctr, Otorhinolaryngol Unit, Via Alessandro Manzoni 56, I-20089 Rozzano, MI, Italy

来源：

AUTOIMMUNITY REVIEWS | 2018年 / 17卷 / 03期

关键词：

Neuromyelitis optica; Neuromyelitis optica spectrum disorders; Aquaporin-4 immunoglobulin G; Diagnostic criteria; Management; INTERLEUKIN-6 RECEPTOR BLOCKADE; AQUAPORIN WATER CHANNELS; LONG-TERM COURSE; MULTIPLE-SCLEROSIS; ELASTASE INHIBITOR; CLINICAL-FEATURES; IMMUNOGLOBULIN-G; NMO; MECHANISMS; CRITERIA;

D O I：

10.1016/j.autrev.2018.01.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neuromyelitis optica (NMO) and Neuromyelitis optica spectrum disorders (NMOSD) are a group of autoimmune conditions characterized by inflammatory involvement of the optic nerve, spinal cord and central nervous system. Novel evidence showed a key role of autoantibodies against aquaporin-4 immunoglobulin G (AQP4 IgG) in the pathogenesis of NMOSD and, recently, new classification and diagnostic criteria have been adopted to facilitate an earlier identification and improve the management of these conditions. Diagnosis of NMOSD is currently based on clinical, neuroimaging and laboratory features. Standard treatment is based on the use of steroids and immunosuppressive drugs and aims to control the severity of acute attacks and to prevent relapses of the disease. This review gives an update of latest knowledge of NMOSD and NMO, emphasizing the novel diagnostic criteria and both current and future therapeutic approaches. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：195 / 200

页数：6

共 79 条

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