The impact of chemotherapy-related nausea on patients' nutritional status, psychological distress and quality of life

被引:111
作者
Farrell, Carole [2 ]
Brearley, Sarah G. [3 ]
Pilling, Mark [1 ]
Molassiotis, Alex [1 ]
机构
[1] Univ Manchester, Sch Nursing Midwifery & Social Work, Manchester M13 9PL, Lancs, England
[2] Christie NHS Fdn Trust, Manchester, Lancs, England
[3] Univ Lancaster, Fac Hlth & Med, Lancaster, England
关键词
Nausea; Chemotherapy; Nutrition; Anxiety; Depression; Quality of life; Physical functioning; SUBJECTIVE GLOBAL ASSESSMENT; MODERATELY EMETOGENIC CHEMOTHERAPY; BREAST-CANCER PATIENTS; POSTCHEMOTHERAPY NAUSEA; RECEIVING CHEMOTHERAPY; BODY-COMPOSITION; ROUTINE PRACTICE; SCALE; QUESTIONNAIRE; VALIDATION;
D O I
10.1007/s00520-012-1493-9
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Nausea is a troublesome and distressing symptom for patients receiving chemotherapy. While vomiting is well controlled with current antiemetics, nausea is a more difficult symptom to manage. The aim of this study was to assess the impact of nausea on nutritional status, quality of life and psychological distress. This was a prospective observational study over two cycles of chemotherapy. Patients completed the Multinational Association of Supportive Care in Cancer Antiemesis Tool, a measure of nutritional status (Patient-Generated Subjective Global Assessment), the Functional Assessment of Cancer Therapy-General (FACT-G) quality of life scale and the Hospital Anxiety and Depression Scale at the end of each chemotherapy cycle (around day 10 post-chemotherapy). The sample consisted of 104 patients, primarily female, receiving anthracycline-based chemotherapy. While vomiting was minimal (5.2-14.6 % of the patients), high levels of nausea were observed (55.2-72.9 %), and severe nausea (> 6 on a 0-10 scale) was reported by 20.5-29.2 % of the participants. Severe nausea had a borderline significant impact in relation to physical functioning (p = 0.025) and a significant impact on nutritional status (severe acute nausea, p = 0.003; severe delayed nausea, p = 0.017). Clinically meaningful changes were observed in relation to the FACT-G total score. Chemotherapy-induced nausea does have an impact on nutritional status and physical functioning and can impair anxiety and quality of life. As a key symptom associated with other symptoms, it is imperative that greater attention is given to managing treatment-related nausea through innovative non-pharmacological and nutritional interventions.
引用
收藏
页码:59 / 66
页数:8
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