Ramariolides A-D, Antimycobacterial Butenolides Isolated from the Mushroom Ramaria cystidiophora

被引：39

作者：

Centko, Ryan M. ^{[1
,2
]}

Ramon-Garcia, Santiago ^{[3
,4
]}

Taylor, Terry ^{[3
]}

Patrick, Brian O. ^{[1
,2
]}

Thompson, Charles J. ^{[3
,4
]}

Miao, Vivian P. ^{[3
]}

Andersen, Raymond J. ^{[1
,2
]}

机构：

[1] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada

[2] Univ British Columbia, Dept Earth Ocean & Atmospher Sci, Vancouver, BC V6T 1Z1, Canada

[3] Univ British Columbia, Dept Microbiol & Immunol, Vancouver, BC V6T 1Z3, Canada

[4] Univ British Columbia, Ctr TB Res, Vancouver, BC V6T 1Z3, Canada

来源：

JOURNAL OF NATURAL PRODUCTS | 2012年 / 75卷 / 12期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1021/np3006277

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four butenolides, ramariolides A-D (1-4), have been isolated from the fruiting bodies of the coral mushroom Ramaria cystidiophora. Their structures were elucidated by analysis of ID and 2D NMR data and a single-crystal X-ray diffraction analysis of 1, and their absolute configurations were established using Mosher's method. The major metabolite, ramariolide A (1), which contains an unusual spiro oxiranebutenolide moiety, showed in vitro antimicrobial activity against Mycobacterium smegmatis and Mycobacterium tuberculosis.

引用

页码：2178 / 2182

页数：5

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