The role of IL-13 in helminth-induced inflammation and protective immunity against nematode infections

被引：102
作者：
Finkelman, FD
Wynn, TA
Donaldson, DD
Urban, JF
机构：
[1] Univ Cincinnati, Coll Med, Div Immunol, Cincinnati, OH 45267 USA
[2] Vet Adm Med Ctr, Res Serv 151, Cincinnati, OH 45220 USA
[3] NIH, Parasit Dis Lab, Bethesda, MD 20892 USA
[4] Genet Inst Inc, Cambridge, MA 02140 USA
[5] ARS, Immunol Dis Resistance Lab, Inst Livestock & Poultry Sci, USDA,Beltsville Agr Res Ctr E, Beltsville, MD 20705 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 1999年 / 11卷 / 04期
关键词：
D O I：
10.1016/S0952-7915(99)80070-3
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Helminth infections induce the production of type 2 cytokines, which contribute both to expulsion of the worms and inflammatory responses that can either protect or damage the host. Although IL-4 has been considered the most critical cytokine for both inflammation and protective immunity, recent observations indicate that IL-13 - a related cytokine - can have equal or even greater importance than IL-4 in inflammatory responses and host protection against infection.
引用
收藏
页码：420 / 426
页数：7
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