The role of IL-13 in helminth-induced inflammation and protective immunity against nematode infections

被引：102

作者：

Finkelman, FD

Wynn, TA

Donaldson, DD

Urban, JF

机构：

[1] Univ Cincinnati, Coll Med, Div Immunol, Cincinnati, OH 45267 USA

[2] Vet Adm Med Ctr, Res Serv 151, Cincinnati, OH 45220 USA

[3] NIH, Parasit Dis Lab, Bethesda, MD 20892 USA

[4] Genet Inst Inc, Cambridge, MA 02140 USA

[5] ARS, Immunol Dis Resistance Lab, Inst Livestock & Poultry Sci, USDA,Beltsville Agr Res Ctr E, Beltsville, MD 20705 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1999年 / 11卷 / 04期

关键词：

D O I：

10.1016/S0952-7915(99)80070-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Helminth infections induce the production of type 2 cytokines, which contribute both to expulsion of the worms and inflammatory responses that can either protect or damage the host. Although IL-4 has been considered the most critical cytokine for both inflammation and protective immunity, recent observations indicate that IL-13 - a related cytokine - can have equal or even greater importance than IL-4 in inflammatory responses and host protection against infection.

引用

页码：420 / 426

页数：7

共 85 条

[1] cDNA cloning and characterization of the human interleukin 13 receptor alpha chain [J].