Photobiomodulation and visual stimulation against cognitive decline and Alzheimer's disease pathology: A systematic review

被引：15

作者：

Monteiro, Francisca ^{[1
,2
,3
]}

Carvalho, Oscar ^{[1
,3
]}

Sousa, Nuno ^{[2
,4
]}

Silva, Filipe S. ^{[1
,3
]}

Sotiropoulos, Ioannis ^{[2
,4
,5
]}

机构：

[1] Univ Minho, Ctr Microelectromechan Syst CMEMS, Campus Azurem, P-4800058 Guimaraes, Portugal

[2] ICVS 3Bs PT Govt Associate Lab, Braga, Portugal

[3] Univ Minho, Associate Lab, LABBELS, Guimaraes, Portugal

[4] Univ Minho, Life & Hlth Sci Res Inst ICVS, Sch Med, Campus Gualtar, P-4710057 Braga, Portugal

[5] NCSR Demokritos, Inst Biosci & Applicat, Athens, Greece

来源：

ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS | 2022年 / 8卷 / 01期

关键词：

Alzheimer's disease; cognitive decline; light-based therapies; photobiomodulation; visual stimulation; LEVEL LASER THERAPY; TRANSCRANIAL LED THERAPY; MOUSE MODEL; CELL APOPTOSIS; LIGHT; BRAIN; PROPAGATION; DYSFUNCTION; RESPONSES; STRESS;

D O I：

10.1002/trc2.12249

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

IntroductionGiven the ineffectiveness of the available drug treatment against Alzheimer disease (AD), light-based therapeutic modalities have been increasingly receiving attention with photobiomodulation (PBM) and, more recently, visual stimulation (VS) being among the most promising approaches. However, the PBM and VS light parameters tested so far, as well as their outcomes, vary a lot with conflicting results being reported. MethodsBased on Scopus, PubMed, and Web of Science databases search, this systematic review summarizes, compares, and discusses 43 cell, animal, and human studies of PBM and VS related to cognitive decline and AD pathology. ResultsPreclinical work suggests that PBM with 640 +/- 30-nm light and VS at 40 Hz attenuates A beta and Tau pathology and improves neuronal and synaptic plasticity with most studies pointing towards enhancement of degradation/clearance mechanisms in the brain of AD animal models. Despite the gap of the translational evidence for both modalities, the few human studies performed so far support the use of PBM at 810-870 nm light pulsing at 40 Hz for improving brain network connectivity and memory in older subjects and AD patients, while 40 Hz VS in humans seems to improve cognition; further clinical investigation is urgently required to clarify the beneficial impact of PBM and VS in AD patients. DiscussionThis review highlights PBM and VS as promising light-based therapeutic approaches against AD brain neuropathology and related cognitive decline, clarifying the most effective light parameters for further preclinical and clinical testing and use. HighlightsLight-based brain stimulation produces neural entrainment and reverts neuronal damageBrain PBM and VS attenuate AD neuropathologyPMB and VS are suggested to improve cognitive performance in AD patients and animal modelsLight stimulation represents a promising therapeutic strategy against neurodegeneration

引用

页数：24

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