Exosome biogenesis, secretion and function of exosomal miRNAs in skeletal muscle myogenesis

被引：213

作者：

Yue, Binglin ^{[1
]}

Yang, Haiyan ^{[1
]}

Wang, Jian ^{[1
]}

Ru, Wenxiu ^{[1
]}

Wu, Jiyao ^{[1
]}

Huang, Yongzheng ^{[1
]}

Lan, Xianyong ^{[1
]}

Lei, Chuzhao ^{[1
]}

Chen, Hong ^{[1
]}

机构：

[1] Northwest A&F Univ, Coll Anim Sci & Technol, Key Lab Anim Genet Breeding & Reprod Shaanxi Prov, Yangling 712100, Shaanxi, Peoples R China

来源：

CELL PROLIFERATION | 2020年 / 53卷 / 07期

基金：

中国国家自然科学基金;

关键词：

exosomal miRNAs; exosome; non-coding RNA; skeletal muscle; EXTRACELLULAR VESICLES; MOLECULAR REGULATION; INSULIN-RESISTANCE; ADIPOSE-TISSUE; CIRCULAR RNA; STEM-CELLS; PROTEINS; CANCER; MICRORNAS; TARGET;

D O I：

10.1111/cpr.12857

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Exosomes are membrane-bound extracellular vesicles that are produced in the endosomal compartment of most mammalian cell types and then released. Exosomes are effective carriers for the intercellular material transfer of material that can influence a series of physiological and pathological processes in recipient cells. Among loaded cargoes, non-coding RNAs (ncRNAs) vary for the exosome-producing cell and its homeostatic state, and characterization of the biogenesis and secretion of exosomal ncRNAs and the functions of these ncRNAs in skeletal muscle myogenesis remain preliminary. In this review, we will describe what is currently known of exosome biogenesis, release and uptake of exosomal ncRNAs, as well as the varied functions of exosomal miRNAs in skeletal muscle myogenesis.

引用

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