Heterocyclization of N-(1-chloro-2,2,2-trifluoroethylidene)carbamates with β-enaminoesters-a novel synthetic strategy to functionalized trifluoromethylated pyrimidines

被引：26

作者：

Sukach, Volodymyr A. ^{[1
]}

Tkachuk, Viktor M. ^{[1
]}

Rusanov, Eduard B. ^{[1
]}

Roeschenthaler, Gerd-Volker ^{[2
]}

Vovk, Mykhaylo V. ^{[2
]}

机构：

[1] Natl Acad Sci Ukraine, Inst Organ Chem, UA-02094 Kiev, Ukraine

[2] Jacobs Univ Bremen, Sch Sci & Engn, D-28759 Bremen, Germany

来源：

TETRAHEDRON | 2012年 / 68卷 / 40期

关键词：

Pyrimidines; Heterocyclization; Enamines; Trifluoromethyl group; N-(1-Chloro-2,2,2-trifluoroethylidene)carbamates; 1-CHLOROALKYL ISOCYANATES; 1-CHLOROBENZYL ISOCYANATES; ACID-ESTERS; HETEROCUMULENES; CYCLOCONDENSATION; DERIVATIVES; C; O; 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES; N-BINUCLEOPHILES; O-BINUCLEOPHILES;

D O I：

10.1016/j.tet.2012.07.099

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel synthetic strategy to 4-trifluoromethyl substituted 2-oxo-1,2-dihydropyrimidine-5-carboxylates has been developed based on the cyclocondensation of beta-enaminoesters with N-(1-chloro-2,2,2trifluoroethylidene)carbamates. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：8408 / 8415

页数：8

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