Ir-Catalyzed Enantioselective Hydrogenation of 2H-1,4-Benzoxazines with a Chiral 1,2,3,4-Tetrahydro-1-naphthylamine Derived Phosphine-aminophosphine Ligand

被引：14

作者：

Hu Juan ^{[1
]}

Wang Daoyong ^{[1
]}

Zheng Zhuo ^{[1
]}

Hu Xiangping ^{[1
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2012年 / 30卷 / 11期

关键词：

asymmetric catalysis; hydrogenation; iridium; 2H-1; 4-benzoxazine; phosphine-aminophosphine ligand; ASYMMETRIC HYDROGENATION; KINETIC RESOLUTION; PRACTICAL LIGANDS; INTERMEDIATE; (+/-)-2,3-DIHYDRO-3-METHYL-4H-1,4-BENZOXAZINE; ALKALOIDS; CHLORIDE; IRIDIUM; ESTER; ARYL;

D O I：

10.1002/cjoc.201200944

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Unsymmetrical hybrid chiral phosphine-aminophosphine ligand derived from 1,2,3,4-tetrahydro-1-naphthylamine has been found to be highly efficient in the Ir-catalyzed asymmetric hydrogenation of various 3-aryl-2H-1,4-benzoxazines, providing good enantioselectivities (up to 95% ee) and high catalytic activity (S/C up to 5000).

引用

页码：2664 / 2668

页数：5

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