Frequency domain multiplexing for speckle reduction in optical coherence tomography

被引：16

作者：

van Soest, Gijs ^{[1
]}

Villiger, Martin ^{[2
]}

Regar, Evelyn ^{[1
]}

Tearney, Guillermo J. ^{[2
]}

Bouma, Brett E. ^{[2
]}

van der Steen, Antonius F. W. ^{[1
,3
]}

机构：

[1] Erasmus MC, Ctr Thorax, NL-3000 CA Rotterdam, Netherlands

[2] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA

[3] Interuniv Cardiol Inst Netherlands, Utrecht, Netherlands

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2012年 / 17卷 / 07期

关键词：

optical coherence tomography; speckle; filtering; image processing; quantitative analysis; intravascular imaging; ATTENUATION COEFFICIENTS; IMAGES; MICROSCOPY; TISSUES;

D O I：

10.1117/1.JBO.17.7.076018

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Quantitative analysis of optical coherence tomography data can be strongly hampered by speckle. Here, we introduce a new method to reduce speckle, which leverages from Fourier-domain configurations and operates on individual axial scans. By subdividing the digitized spectrum into a number of distinct narrower windows, each with a different center frequency, several independent speckle patterns result. These can be averaged to yield a lower-resolution image with strongly reduced speckle. The full resolution image remains available for human interpretation; the low resolution version can be used for parametric imaging or quantitative analysis. We demonstrate this technique using intravascular optical frequency domain imaging data acquired in vivo. (C) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.JBO.17.7.076018]

引用

页数：7

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