Lessons from Exploring Chemical Space and Chemical Diversity of Propolis Components

被引：41

作者：

Tran, Trong D. ^{[1
]}

Ogbourne, Steven M. ^{[1
]}

Brooks, Peter R. ^{[1
]}

Sanchez-Cruz, Norberto ^{[2
]}

Medina-Franco, Jose L. ^{[2
]}

Quinn, Ronald J. ^{[3
]}

机构：

[1] Univ Sunshine Coast, GeneCol Res Ctr, Sch Sci & Engn, Maroochydore, Qld 4558, Australia

[2] Univ Nacl Autonoma Mexico, Sch Chem, Dept Pharm, Mexico City 04510, DF, Mexico

[3] Griffith Univ, Griffith Inst Drug Discovery, Brisbane, Qld 4111, Australia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 14期

关键词：

honey bee propolis; stingless bee propolis; natural products; phenolics; terpenoids; chemoinformatics; chemical space; chemical diversity; ACID PHENETHYL ESTER; BRAZILIAN RED PROPOLIS; KANGAROO ISLAND PROPOLIS; ALPHA-MANGOSTIN; IN-VITRO; ARTEPILLIN-C; POLYISOPRENYLATED BENZOPHENONES; NEPALESE PROPOLIS; NATURAL-PRODUCTS; STINGLESS BEES;

D O I：

10.3390/ijms21144988

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Propolis is a natural resinous material produced by bees and has been used in folk medicines since ancient times. Due to it possessing a broad spectrum of biological activities, it has gained significant scientific and commercial interest over the last two decades. As a result of searching 122 publications reported up to the end of 2019, we assembled a unique compound database consisting of 578 components isolated from both honey bee propolis and stingless bee propolis, and analyzed the chemical space and chemical diversity of these compounds. The results demonstrated that both honey bee propolis and stingless bee propolis are valuable sources for pharmaceutical and nutraceutical development.

引用

页码：1 / 35

页数：35

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