Copper-Catalyzed Alkene Arylation with Diaryliodonium Salts

被引：183

作者：

Phipps, Robert J. ^{[1
]}

McMurray, Lindsay ^{[1
]}

Ritter, Stefanie ^{[1
]}

Duong, Hung A. ^{[1
]}

Gaunt, Matthew J. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 26期

基金：

英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

ENANTIOSELECTIVE ALPHA-ARYLATION; CROSS-COUPLING REACTIONS; HECK REACTION; PALLADIUM; ARYL; OLEFINS;

D O I：

10.1021/ja3039807

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Alkenes and arenes represent two classes of feedstock compounds whose union has fundamental importance to synthetic organic chemistry. We report a new approach to alkene arylation using diaryliodonium salts and Cu catalysis. Using a range of simple alkenes, we have shown that the product outcomes differ significantly from those commonly obtained by the Heck reaction. We have used these insights to develop a number of new tandem and cascade reactions that transform readily available alkenes into complex arylated products that may have broad. applications in chemical synthesis.

引用

页码：10773 / 10776

页数：4

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