Chronic Wasting Disease Agents in Nonhuman Primates

被引:56
作者
Race, Brent [1 ]
Meade-White, Kimberly D. [1 ]
Phillips, Katie [1 ]
Striebel, James [1 ]
Race, Richard [1 ]
Chesebro, Bruce [1 ]
机构
[1] NIAID, NIH, Hamilton, MT 59840 USA
关键词
BOVINE SPONGIFORM ENCEPHALOPATHY; HUMAN PRION PROTEIN; TRANSGENIC MICE; TRANSMISSION; HUMANS; MACAQUES; BSE; ELK;
D O I
10.3201/eid2005.130778
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Chronic wasting disease, a prion disease of cervids, may infect humans, but this is unproven. Primates from 2 genera were observed for 9-10 years after intracerebral or oral inoculation. Cynomologus macaques were completely resistant. However, squirrel monkeys were highly susceptible to the pathogen, which adapted more quickly on second passage.
引用
收藏
页码:833 / 837
页数:5
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