The Catalytically Active Copper-Amyloid-Beta State: Coordination Site Responsible for Reactive Oxygen Species Production

被引：105
作者：
Cassagnes, Laure-Estelle [1 ,2 ]
Herve, Vincent [1 ,2 ]
Nepveu, Francoise [1 ,2 ]
Hureau, Christelle [3 ,4 ]
Faller, Peter [3 ,4 ]
Collin, Fabrice [1 ,2 ]
机构：
[1] Univ Toulouse 3, UPS, Univ Toulouse, UMR PHARMA DEV 152, F-31062 Toulouse 09, France
[2] IRD, UMR PHARMA DEV 152, F-31062 Toulouse 09, France
[3] Univ Toulouse, INPT, UPS, F-31077 Toulouse, France
[4] CNRS, LCC, UPR 8241, F-75700 Paris, France
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 42期
关键词：
amyloid-beta peptide; copper; mass spectrometry; reactive oxygen species; redox chemistry; ALZHEIMERS-DISEASE; OXIDATIVE STRESS; CU(II)-CATALYZED OXIDATION; MASS-SPECTROMETRY; PRECURSOR PROTEIN; REDOX CHEMISTRY; CU(II) BINDING; METAL-IONS; PEPTIDE; CONSEQUENCES;
D O I：
10.1002/anie.201305372
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Copper-amyloid-β ROS production: Copper ions (red sphere, see picture) have been found to accumulate in amyloid-β plaques and play a role in the generation of reactive oxygen species (ROS) within this context. Mass spectrometry studies were able to detail the sites of oxidation damage and shed new light on the mechanism of ROS production, important for the understanding of the pathogenicity of amyloid-β peptides. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：11110 / 11113
页数：4
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