Evaluation of Aspergillus IgG, IgM antibody for diagnosing in chronic pulmonary aspergillosis A prospective study from a single center in China

被引：4
作者：
Guo, Yiqun [1 ]
Bai, Yu [1 ]
Yang, Chunxia [1 ]
Gu, Li [1 ]
机构：
[1] Capital Med Univ, Dept Infect Dis & Clin Microbiol, Beijing Chao Yang Hosp, 8 GongTi South Rd, Beijing 100020, Peoples R China
来源：
MEDICINE | 2019年 / 98卷 / 16期
关键词：
Aspergillus IgG; Aspergillus IgM; chronic pulmonary aspergillosis; FUMIGATUS; ASSAY; KIT;
D O I：
10.1097/MD.0000000000015021
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Chronic pulmonary aspergillosis (CPA) is a slowly progressing pulmonary fungal infectious disease caused by Aspergillus. Aspergillus IgG, IgM are now considered to be valuable biomarkers in CPA diagnosing. Our research attempts to evaluate the effectiveness of Aspergillus IgG, IgM in diagnosing CPA. In our study, CPA patients were younger than the patients who suffered other pulmonary disease. The most common underlying disease in CPA patients was pulmonary tuberculosis. And the most common clinical symptom was hemoptysis. The comparison among the groups indicated statistical significance with regard to Aspergillus IgG and IgM between the CPA and other pulmonary disease groups (P <.01). The Aspergillus-specific IgG and IgM in infectious group exhibited higher levels than those in colonization group (P <.01). The area under the receiver operating characteristic curve of Aspergillus IgG was 0.762 (95% confidence interval: 0.664-0.860) (P <.01). Aspergillus-specific IgG offers great diagnostic value with regard to CPA.
引用
收藏
页数：5
相关论文
共 14 条
[1]   Follow-up of anti-Aspergillus IgG and IgA antibodies in bone marrow transplanted patients with invasive aspergillosis [J].
Centeno-Lima, S ;
de Lacerda, JM ;
do Carmo, JA ;
Abecasis, M ;
Casimiro, C ;
Exposto, F .
JOURNAL OF CLINICAL LABORATORY ANALYSIS, 2002, 16 (03) :156-162
[2]   Chronic pulmonary aspergillosis: rationale and clinical guidelines for diagnosis and management [J].
Denning, David W. ;
Cadranel, Jacques ;
Beigelman-Aubry, Catherine ;
Ader, Florence ;
Chakrabarti, Arunaloke ;
Blot, Stijn ;
Ullmann, Andrew J. ;
Dimopoulos, George ;
Lange, Christoph .
EUROPEAN RESPIRATORY JOURNAL, 2016, 47 (01) :45-68
[3]   Chronic cavitary and Fibrosing pulmonary and pleural aspergillosis: Case series, proposed nomenclature change, and review [J].
Denning, DW ;
Riniotis, K ;
Dobrashian, R ;
Sambatakou, H .
CLINICAL INFECTIOUS DISEASES, 2003, 37 :S265-S280
[4]   Prospective Evaluation of a New Aspergillus IgG Enzyme Immunoassay Kit for Diagnosis of Chronic and Allergic Pulmonary Aspergillosis [J].
Dumollard, C. ;
Bailly, S. ;
Perriot, S. ;
Brenier-Pinchart, M. P. ;
Saint-Raymond, C. ;
Camara, B. ;
Gangneux, J. P. ;
Persat, F. ;
Valot, S. ;
Grenouillet, F. ;
Pelloux, H. ;
Pinel, C. ;
Cornet, M. .
JOURNAL OF CLINICAL MICROBIOLOGY, 2016, 54 (05) :1236-1242
[5]   Evaluation of a Quantitative Serological Assay for Diagnosing Chronic Pulmonary Aspergillosis [J].
Fujiuchi, Satoru ;
Fujita, Yuka ;
Suzuki, Hokuto ;
Doushita, Kazushi ;
Kuroda, Hikaru ;
Takahashi, Masaaki ;
Yamazaki, Yasuhiro ;
Tsuji, Tadakatsu ;
Fujikane, Toshiaki ;
Osanai, Shinobu ;
Sasaki, Takaaki ;
Ohsaki, Yoshinobu .
JOURNAL OF CLINICAL MICROBIOLOGY, 2016, 54 (06) :1496-1499
[6]   Clinical characteristics and treatment outcomes of chronic pulmonary aspergillosis [J].
Jhun, Byung Woo ;
Jeon, Kyeongman ;
Eom, Jung Seop ;
Lee, Ji Hyun ;
Suh, Gee Young ;
Kwon, O. Jung ;
Koh, Won-Jung .
MEDICAL MYCOLOGY, 2013, 51 (08) :811-817
[7]   CLASS-SPECIFIC ANTIBODY DETERMINATION AGAINST ASPERGILLUS-FUMIGATUS BY MEANS OF THE ENZYME-LINKED-IMMUNOSORBENT-ASSAY .3. COMPARATIVE-STUDY - IGG, IGA, IGM ELISA TITERS, PRECIPITATING ANTIBODIES AND IGE BINDING AFTER FRACTIONATION OF THE ANTIGEN [J].
KAUFFMAN, HF ;
VANDERHEIDE, S ;
BEAUMONT, F ;
BLOK, H ;
DEVRIES, K .
INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1986, 80 (03) :300-306
[8]   Comparison of Aspergillus galactomannan antigen testing with a new cut-off index and Aspergillus precipitating antibody testing for the diagnosis of chronic pulmonary aspergillosis [J].
Kitasato, Yasuhiko ;
Tao, Yoshiaki ;
Hoshino, Tomoaki ;
Tachibana, Kousuke ;
Inoshima, Naoko ;
Yoshida, Makoto ;
Takata, Shohei ;
Okabayashi, Kan ;
Kawasaki, Masayuki ;
Iwanaga, Tomoaki ;
Aizawa, Hisamichi .
RESPIROLOGY, 2009, 14 (05) :701-708
[9]  
Kume Hikaru, 2011, Med Mycol J, V52, P117, DOI 10.3314/jjmm.52.117
[10]   PROGNOSTIC FACTORS FOR SURVIVAL OF 194 PATIENTS WITH LOW INFILTRATE LEUKEMIA [J].
MADDOX, AM ;
KEATING, MJ ;
SMITH, TL ;
SPEER, J ;
CORK, MA ;
TRUJILLO, JM ;
MCCREDIE, KB ;
FREIREICH, EJ .
LEUKEMIA RESEARCH, 1986, 10 (08) :995-1006
12