Virus isolation, genetic characterization and seroprevalence of Toscana virus in Algeria

被引：40
作者：
Alkan, C. [1 ,2 ]
Allal-Ikhlef, A. B. [3 ]
Alwassouf, S. [1 ,2 ]
Baklouti, A. [1 ,2 ]
Piorkowski, G. [1 ,2 ]
de Lamballerie, X. [1 ,2 ]
Izri, A. [4 ]
Charrel, R. N. [1 ,2 ]
机构：
[1] Aix Marseille Univ, IRD French Inst Res Dev, EHESP French Sch Publ Hlth, EPV UMR D 190 Emergence Pathol Virales, Marseille, France
[2] APHM Publ Hosp Marseille, IHU Mediterranee Infect, Marseille, France
[3] Univ Oran 1, Fac Sci Nat & Vie, Dept Biol, Ahmed Ben Bella, Algeria
[4] Univ Paris, Hop Avicenne, Serv Parasitol Mycol, F-75252 Paris, France
来源：
CLINICAL MICROBIOLOGY AND INFECTION | 2015年 / 21卷 / 11期
关键词：
Complete genome sequencing; microneutralization; Phlebovirus; seroprevalence; Toscana virus; vector-borne infection; SANDFLY FEVER VIRUS; LEISHMANIA-INFANTUM; NESTED-PCR; INFECTION; PHLEBOVIRUSES; TUSCANY; IDENTIFICATION; EPIDEMIOLOGY; OUTBREAK; FLIES;
D O I：
10.1016/j.cmi.2015.07.012
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Toscana virus (TOSV; Bunyaviridae, Phlebovirus) is transmitted by sandflies of the genus Phlebotomus in the Mediterranean area. One strain of TOSV was isolated from a total of almost 23 000 sandflies collected in Kabylia, Algeria. The complete genome was sequenced, and phylogenetic studies indicated that it was most closely related with TOSV strain from Tunisia within lineage A, which also includes Italian, French and Turkish strains. A seroprevalence study performed on 370 sera collected from people living in the same area showed that almost 50% possessed neutralizing antibodies against TOSV, a rate much higher than that observed in Southern Europe. Sandfly species distribution in the study area suggests that the vector of TOSV in this region belongs to the subgenus Larroussius. These data support the rapid implementation of the diagnosis of TOSV in clinical microbiology laboratories to estimate the burden in patients presenting with neuroinvasive infections and febrile illness. Clinical Microbiology and Infection (C) 2015 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：1040.e1 / 1040.e9
页数：9
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