Fabrication of solid lipid microcapsules containing ascorbic acid using a microfluidic technique

被引:70
作者
Comunian, Talita A. [1 ]
Abbaspourrad, Alireza [2 ,3 ]
Favaro-Trindade, Carmen S. [1 ]
Weitz, David A. [2 ,3 ]
机构
[1] Univ Sao Paulo, Fac Zootecnia & Engn Alimentos, BR-13535900 Pirassununga, SP, Brazil
[2] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA
[3] Harvard Univ, Dept Phys, Cambridge, MA 02138 USA
基金
巴西圣保罗研究基金会;
关键词
Encapsulation; Vitamin C; Encapsulation efficiency; Lipid shell; VITAMIN-C; ENCAPSULATION; MICROENCAPSULATION; STABILITY; COMPLEX;
D O I
10.1016/j.foodchem.2013.11.149
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
The importance of ascorbic acid (AA) in the human diet has motivated food researchers to develop AA-fortified food products. However, this compound is very unstable. The aim of this work was to produce solid lipid microcapsules (SLMs) loaded with AA using microfluidic technology. The morphology of the SLMs was analysed by optical, scanning electron and confocal microscopy. We determined the encapsulation efficiency, particle size and stability of the encapsulated material. Two different means of enhancing the encapsulation efficiency and stability of AA were demonstrated: a pore blocking method and a micromolecule-chelating agent within the core. The results indicated the enormous potential of the designed vehicle to prevent AA degradation in a food product; additionally, this vehicle could mask the acidic taste of AA. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码:271 / 275
页数:5
相关论文
共 14 条
[1]   Encapsulation of ascorbic acid in amorphous maltodextrin employing extrusion as affected by matrix/core ratio and water content [J].
Chang, Dawei ;
Abbas, Shabbar ;
Hayat, Khizar ;
Xia, Shuqin ;
Zhang, Xiaoming ;
Xie, Mingyong ;
Kim, Jin Moon .
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 2010, 45 (09) :1895-1901
[2]   Microencapsulation of ascorbic acid by complex coacervation: Protection and controlled release [J].
Comunian, Talita A. ;
Thomazini, Marcelo ;
Gouvea Alves, Ana Julia ;
de Matos Junior, Fernando Eustaquio ;
de Carvalho Balieiro, Julio C. ;
Favaro-Trindade, Carmen S. .
FOOD RESEARCH INTERNATIONAL, 2013, 52 (01) :373-379
[3]   Characteristics of vitamin C immobilized particles and sodium alginate beads containing immobilized particles [J].
Desai, KGH ;
Liu, C ;
Park, HJ .
JOURNAL OF MICROENCAPSULATION, 2005, 22 (04) :363-376
[4]   A simple and reliable spectrophotometric method for the determination of ascorbic acid in pharmaceutical preparations [J].
Farajzadeh, MA ;
Nagizadeh, S .
JOURNAL OF ANALYTICAL CHEMISTRY, 2003, 58 (10) :927-932
[5]   Encapsulation of ascorbic acid in liposomes prepared with milk fat globule membrane-derived phospholipids [J].
Farhang, Bita ;
Kakuda, Yukio ;
Corredig, Milena .
DAIRY SCIENCE & TECHNOLOGY, 2012, 92 (04) :353-366
[6]   Fluid-bed microencapsulation of ascorbic acid [J].
Knezevic, Z ;
Gosak, D ;
Hraste, M ;
Jalsenjak, I .
JOURNAL OF MICROENCAPSULATION, 1998, 15 (02) :237-252
[7]   Stability of vitamins C and E in topical microemulsions for combined antioxidant therapy [J].
Rozman, Branka ;
Gasperlin, Mirjana .
DRUG DELIVERY, 2007, 14 (04) :235-245
[8]  
SAS, 1995, SAS US GUID BAS STAT
[9]   Microfluidic Melt Emulsification for Encapsulation and Release of Actives [J].
Sun, Bing Jie ;
Shum, Ho Cheung ;
Holtze, Christian ;
Weitz, David A. .
ACS APPLIED MATERIALS & INTERFACES, 2010, 2 (12) :3411-3416
[10]   Controlled microfluidic encapsulation of cells, proteins, and microbeads in lipid vesicles [J].
Tan, YC ;
Hettiarachchi, K ;
Siu, M ;
Pan, YP .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (17) :5656-5658