Increased Folate Intake with No Changes in Serum Homocysteine and Decreased Levels of C-Reactive Protein in Patients with Inflammatory Bowel Diseases

被引:18
作者
Chiarello, P. G. [1 ]
Penaforte, F. R. O. [1 ]
Japur, C. C. [1 ]
Souza, C. D. A. S. [1 ]
Vannucchi, H. [1 ]
Troncon, L. E. A. [1 ]
机构
[1] USP, Fac Med, Dept Internal Med, BR-14049190 Ribeirao Preto, SP, Brazil
关键词
Inflammatory bowel disease; Homocysteine; Folic acid; C-reactive protein; ULCERATIVE-COLITIS; CROHNS-DISEASE; METHYLENETETRAHYDROFOLATE REDUCTASE; THROMBOEMBOLIC COMPLICATIONS; FOLIC-ACID; PREVALENCE; HYPERHOMOCYSTEINEMIA; MARKERS; WOMEN; RISK;
D O I
10.1007/s10620-008-0398-4
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
In order to increase dietary folic acid intake and to improve nutritional status regarding folate by controlling homocysteine concentrations, ten patients with inflammatory bowel diseases (Crohn's disease in the colon and ulcerative colitis) received individualized nutritional guidance and were followed up as outpatients for 2 months. The following procedures were performed at the beginning of the study (T0), after 1 month (T1) and at the end of the study (T2): collection of anthropometric data (weight and height), dietary data (24 h diet recall), and blood under fasting condition for the determination of serum folic acid, homocysteine, C-reactive protein, and vitamin B12. Plasma folic acid deficiency was not detected but hyperhomocysteinemia was present in six individuals and C-reactive protein (CRP) was increased (> 0.5 mg/dl) in seven patients. After the patients were instructed there was a significant increase in vitamin B6 intake (about 35%) and in folate intake (49.6%). Mean plasma levels of folic acid, homocysteine, and vitamin B12 did not change, but there was a significant decrease of CRP at T1, 0.36 mg dl(-1) on average (P = 0.01), which was maintained at T2. We conclude that the increased folate intake reported by this group of patients was not reflected in improved serum concentrations of folic acid and homocysteine. However, the guidelines for the patients probably induced them to choose a more adequate diet, providing nutrients that help control the inflammatory process.
引用
收藏
页码:627 / 633
页数:7
相关论文
共 50 条
[31]   Serum C-reactive Protein and CRP Genotype in Pediatric Inflammatory Bowel Disease: Influence on Phenotype, Natural History, and Response to Therapy [J].
Henderson, Paul ;
Kennedy, Nicholas A. ;
Van Limbergen, Johan E. ;
Cameron, Fiona L. ;
Satsangi, Jack ;
Russell, Richard K. ;
Wilson, David C. .
INFLAMMATORY BOWEL DISEASES, 2015, 21 (03) :596-605
[32]   Association between C-reactive protein and homocysteine with the subcomponents of metabolic syndrome in stable patients with bipolar disorder and schizophrenia [J].
Vuksan-Cusa, Bjanka ;
Sagud, Marina ;
Jakovljevic, Miro ;
Peles, Alma Mihaljevic ;
Jaksic, Nenad ;
Mihaljevic, Sanea ;
Zivkovic, Maja ;
Mikulic, Suzan Kudlek ;
Jevtovic, Sasa .
NORDIC JOURNAL OF PSYCHIATRY, 2013, 67 (05) :320-325
[33]   Evaluation of C-reactive protein and serum amyloid A in the detection of inflammatory and infectious diseases in children [J].
dos Anjos, Barbara L. ;
Grotto, Helena Z. W. .
CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2010, 48 (04) :493-499
[34]   Effects of training on resting plasma levels of homocysteine and C-reactive protein in competitive male and female wrestlers [J].
Huebner-Wozniak, Elzbieta ;
Ochocki, Patryk .
BIOMEDICAL HUMAN KINETICS, 2009, 1 :42-46
[35]   Serum vitamin B12 and folate status in patients with inflammatory bowel diseases [J].
Yakut, Mustafa ;
Ustun, Yusuf ;
Kabacam, Goekhan ;
Soykan, Irian .
EUROPEAN JOURNAL OF INTERNAL MEDICINE, 2010, 21 (04) :320-323
[36]   Dietary antioxidant capacity is associated with improved serum antioxidant status and decreased serum C-reactive protein and plasma homocysteine concentrations [J].
Yang, Meng ;
Chung, Sang-Jin ;
Floegel, Anna ;
Song, Won O. ;
Koo, Sung I. ;
Chun, Ock K. .
EUROPEAN JOURNAL OF NUTRITION, 2013, 52 (08) :1901-1911
[37]   High-sensitivity C-reactive protein in paediatric inflammatory bowel disease [J].
Sidoroff, Marianne ;
Karikoski, Riitta ;
Raivio, Taneli ;
Savilahti, Erkki ;
Kolho, Kaija-Leena .
WORLD JOURNAL OF GASTROENTEROLOGY, 2010, 16 (23) :2901-2906
[38]   High-sensitivity C-reactive protein in paediatric inflammatory bowel disease [J].
Marianne Sidoroff ;
Riitta Karikoski ;
Taneli Raivio ;
Erkki Savilahti ;
Kaija-Leena Kolho .
World Journal of Gastroenterology, 2010, 16 (23) :2901-2906
[39]   C-REACTIVE PROTEIN SERUM LEVELS IN PATIENTS WITH OCULAR DISEASE [J].
TERVO, T ;
VANSETTEN, GB ;
HOVI, M ;
PAKARINEN, M ;
TARKKANEN, A ;
VALTONEN, V .
ACTA OPHTHALMOLOGICA, 1994, 72 (01) :110-113
[40]   CLINICAL SIGNIFICANCE OF C-REACTIVE PROTEIN LEVELS IN PREDICTING RESPONSIVENESS TO IRON THERAPY IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE AND IRON DEFICIENCY ANEMIA [J].
Otea, Andreea-Georgiana ;
Popa, Raluca Cezara ;
Popa, Iolanda Valentina ;
Bejinariu, I. P. ;
Cardoneanu, Anca ;
Gavrilescu, Otilia ;
Dranga, Mihaela ;
Prelipcean, Cristina Cijevschi ;
Mihai, Catalina .
MEDICAL-SURGICAL JOURNAL-REVISTA MEDICO-CHIRURGICALA, 2019, 123 (01) :70-76