The Gluten-Free Diet: Testing Alternative Cereals Tolerated by Celiac Patients

被引:54
作者
Comino, Isabel [1 ]
de Lourdes Moreno, Maria [1 ]
Real, Ana [1 ]
Rodriguez-Herrera, Alfonso [2 ]
Barro, Francisco [3 ]
Sousa, Carolina [1 ]
机构
[1] Univ Seville, Fac Farm, Dept Microbiol & Parasitol, C Prof Garcia Gonzalez 2, E-41012 Seville, Spain
[2] Inst Hispalense Pediat, Seville 41013, Spain
[3] CSIC, Inst Agr Sostenible, Cordoba 14004, Spain
来源
NUTRIENTS | 2013年 / 5卷 / 10期
关键词
celiac disease; gluten-free diet; cereals; pseudocereals; gluten detoxification; QUINOA CHENOPODIUM-QUINOA; LACTIC-ACID BACTERIA; T-CELL EPITOPES; GLIADIN PEPTIDES; RNA INTERFERENCE; DISEASE PATIENTS; TRITICUM-MONOCOCCUM; NUTRITIONAL QUALITY; TARTARY BUCKWHEAT; BREAD WHEAT;
D O I
10.3390/nu5104250
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
A strict gluten-free diet (GFD) is the only currently available therapeutic treatment for patients with celiac disease, an autoimmune disorder of the small intestine associated with a permanent intolerance to gluten proteins. The complete elimination of gluten proteins contained in cereals from the diet is the key to celiac disease management. However, this generates numerous social and economic repercussions due to the ubiquity of gluten in foods. The research presented in this review focuses on the current status of alternative cereals and pseudocereals and their derivatives obtained by natural selection, breeding programs and transgenic or enzymatic technology, potential tolerated by celiac people. Finally, we describe several strategies for detoxification of dietary gluten. These included enzymatic cleavage of gliadin fragment by Prolyl endopeptidases (PEPs) from different organisms, degradation of toxic peptides by germinating cereal enzymes and transamidation of cereal flours. This information can be used to search for and develop cereals with the baking and nutritional qualities of toxic cereals, but which do not exacerbate this condition.
引用
收藏
页码:4250 / 4268
页数:19
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