Pharmacology on microfluidics: multimodal analysis for studying cell-cell interaction

被引：10
作者：
Delamarche, Emmanuel [1 ]
Tonna, Noemi [2 ,3 ]
Lovchik, Robert D. [1 ]
Bianco, Fabio [2 ]
Matteoli, Michela [4 ,5 ]
机构：
[1] IBM Res GmbH, CH-8803 Ruschlikon, Switzerland
[2] Neurozone Srl, Milan, Italy
[3] CNR IN, Milan, Italy
[4] Univ Milan, Dept Med Biotechnol & Translat Med, Milan, Italy
[5] Humanitas Clin & Res Ctr, Rozzano, Italy
来源：
CURRENT OPINION IN PHARMACOLOGY | 2013年 / 13卷 / 05期
关键词：
DIGITAL MICROFLUIDICS; CULTURE; NETWORKS; PLATFORM; SYSTEM; MODEL; DEVICE;
D O I：
10.1016/j.coph.2013.07.005
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Understanding the mechanisms of cell-cell interaction is a key unanswered question in modern pharmacology, given crosstalk defects are at the basis of many pathologies. Microfluidics represents a valuable tool for analyzing intercellular communication mediated by transmission of soluble signals, as occurring for example between neurons and glial cells in neuroinflammation, or between tumor and surrounding cells in cancer. However, the use of microfluidics for studying cell behavior still encompasses many technical and biological challenges. In this review, a state of the art of successes, potentials and limitations of microfluidics applied to key biological questions in modern pharmacology is analyzed and commented.
引用
收藏
页码：821 / 828
页数：8
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