Theoretical concepts and the emerging role of taxanes in adjuvant therapy

被引:0
作者
Norton, L [1 ]
机构
[1] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA
关键词
adjuvant; breast cancer; Gompertzian; log kill; paclitaxel; docetaxel; Herceptin;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The proven benefits of adjuvant chemotherapy on disease-free and overall survival in breast cancer can be explained by concepts of cell kill. Interventions which result in greater log kill can be expected to produce improved clinical results. The application of log-kill concepts to human breast cancer growth, which appears to follow Gompertzian kinetics, suggests not only that the use of non-cross-resistant drugs is important, but that dose-dense schedules may have an advantage over conventional schedules of drug administration. Sequential therapy may allow dose-dense administration of cytotoxic agents and encourage the integration of new biological agents into combination regimens, particularly with the taxanes. Ongoing trials in these concepts are reviewed.
引用
收藏
页码:30 / 35
页数:6
相关论文
共 31 条
[1]  
ABE O, 1992, LANCET, V339, P71
[2]  
Abe O, 1998, LANCET, V352, P930
[3]  
[Anonymous], P AM SOC CLIN ONCOL
[4]  
Bajzer Z, 1999, GROWTH DEVELOP AGING, V63, P3
[5]   ANTITUMOR EFFECTS OF DOXORUBICIN IN COMBINATION WITH ANTIEPIDERMAL GROWTH-FACTOR RECEPTOR MONOCLONAL-ANTIBODIES [J].
BASELGA, J ;
NORTON, L ;
MASUI, H ;
PANDIELLA, A ;
COPLAN, K ;
MILLER, WH ;
MENDELSOHN, J .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (16) :1327-1333
[6]   AN INTENSIVE SEQUENCED ADJUVANT CHEMOTHERAPY REGIMEN FOR BREAST-CANCER [J].
BHARDWAJ, S ;
HOLLAND, JF ;
NORTON, L .
CANCER INVESTIGATION, 1993, 11 (01) :6-9
[7]  
BONADONNA G, 1995, JAMA-J AM MED ASSOC, V273, P542
[8]  
Ciardiello F, 2000, CLIN CANCER RES, V6, P2053
[9]  
Devita Vincent T. Jr., 1997, P333
[10]  
GOLDIE JH, 1979, CANCER TREAT REP, V63, P1727