Algorithms for a Single Hormone Closed-Loop Artificial Pancreas: Challenges Pertinent to Chemical Process Operations and Control

被引：1

作者：

Bequette, B. Wayne ^{[1
]}

Cameron, Faye ^{[1
]}

Baysal, Nihat ^{[1
]}

Howsmon, Daniel P. ^{[1
]}

Buckingham, Bruce A. ^{[2
]}

Maahs, David M. ^{[2
,3
]}

Levy, Carol J. ^{[4
]}

机构：

[1] Rensselaer Polytech Inst, Dept Chem & Biol Engn, 110 Eighth St, Troy, NY 12180 USA

[2] Stanford Univ, 780 Welch Rd,CJ320H MC 5776, Palo Alto, CA 94304 USA

[3] Univ Colorado, Barbara Davis Ctr Diabet, 1775 Aurora Court, Denver, CO 80045 USA

[4] Icahn Sch Med Mt Sinai, 1 Gustave A Levy Pl, New York, NY 10029 USA

来源：

PROCESSES | 2016年 / 4卷 / 04期

关键词：

artificial pancreas; glucose control; type; 1; diabetes; TRIAL; SYSTEMS;

D O I：

10.3390/pr4040039

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

The development of a closed-loop artificial pancreas to regulate the blood glucose concentration of individuals with type 1 diabetes has been a focused area of research for over 50 years, with rapid progress during the past decade. The daily control challenges faced by someone with type 1 diabetes include asymmetric objectives and risks, and one-sided manipulated input action with frequent relatively fast disturbances. The major automation steps toward a closed-loop artificial pancreas include (i) monitoring and overnight alarms for hypoglycemia (low blood glucose); (ii) overnight low glucose suspend (LGS) systems to prevent hypoglycemia; and (iii) fully closed-loop systems that adjust insulin (and perhaps glucagon) to maintain desired blood glucose levels day and night. We focus on the steps that we used to develop and test a probabilistic, risk-based, model predictive control strategy for a fully closed-loop artificial pancreas. We complete the paper by discussing ramifications of lessons learned for chemical process systems applications.

引用

页数：11