Algorithms for a Single Hormone Closed-Loop Artificial Pancreas: Challenges Pertinent to Chemical Process Operations and Control

被引:1
作者
Bequette, B. Wayne [1 ]
Cameron, Faye [1 ]
Baysal, Nihat [1 ]
Howsmon, Daniel P. [1 ]
Buckingham, Bruce A. [2 ]
Maahs, David M. [2 ,3 ]
Levy, Carol J. [4 ]
机构
[1] Rensselaer Polytech Inst, Dept Chem & Biol Engn, 110 Eighth St, Troy, NY 12180 USA
[2] Stanford Univ, 780 Welch Rd,CJ320H MC 5776, Palo Alto, CA 94304 USA
[3] Univ Colorado, Barbara Davis Ctr Diabet, 1775 Aurora Court, Denver, CO 80045 USA
[4] Icahn Sch Med Mt Sinai, 1 Gustave A Levy Pl, New York, NY 10029 USA
关键词
artificial pancreas; glucose control; type; 1; diabetes; TRIAL; SYSTEMS;
D O I
10.3390/pr4040039
中图分类号
TQ [化学工业];
学科分类号
0817 ;
摘要
The development of a closed-loop artificial pancreas to regulate the blood glucose concentration of individuals with type 1 diabetes has been a focused area of research for over 50 years, with rapid progress during the past decade. The daily control challenges faced by someone with type 1 diabetes include asymmetric objectives and risks, and one-sided manipulated input action with frequent relatively fast disturbances. The major automation steps toward a closed-loop artificial pancreas include (i) monitoring and overnight alarms for hypoglycemia (low blood glucose); (ii) overnight low glucose suspend (LGS) systems to prevent hypoglycemia; and (iii) fully closed-loop systems that adjust insulin (and perhaps glucagon) to maintain desired blood glucose levels day and night. We focus on the steps that we used to develop and test a probabilistic, risk-based, model predictive control strategy for a fully closed-loop artificial pancreas. We complete the paper by discussing ramifications of lessons learned for chemical process systems applications.
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页数:11
相关论文
共 41 条
[1]   Glycemic Targets [J].
不详 .
DIABETES CARE, 2015, 38 :S33-S40
[2]  
[Anonymous], 2004, National Health and Nutrition Examination Cardiovascular Fitness Procedures Manual
[3]  
[Anonymous], THESIS
[4]  
Banting FG, 1922, CAN MED ASSOC J, V7, P141
[5]  
Baysal Nihat, 2014, J Diabetes Sci Technol, V8, P1091, DOI 10.1177/1932296814553267
[6]  
Baysal N, 2013, P AMER CONTR CONF, P2929
[7]  
Bequette B Wayne, 2005, Diabetes Technol Ther, V7, P28, DOI 10.1089/dia.2005.7.28
[8]  
Bequette B Wayne, 2014, J Diabetes Sci Technol, V8, P1204, DOI 10.1177/1932296814543661
[9]  
Bequette B Wayne, 2013, J Diabetes Sci Technol, V7, P1632
[10]   Challenges and recent progress in the development of a closed-loop artificial pancreas [J].
Bequette, B. Wayne .
ANNUAL REVIEWS IN CONTROL, 2012, 36 (02) :255-266