Photosensitizer-Loaded Gold Vesicles with Strong Plasmonic Coupling Effect for Imaging-Guided Photothermal/Photodynamic Therapy

被引：584

作者：

Lin, Jing ^{[1
,3
]}

Wang, Shouju ^{[2
,4
]}

Huang, Peng ^{[2
,3
]}

Wang, Zhe ^{[2
,5
]}

Chen, Shouhui ^{[2
,3
]}

Niu, Gang ^{[2
]}

Li, Wanwan ^{[2
]}

He, Jie ^{[1
]}

Cui, Daxiang ^{[3
]}

Lu, Guangming ^{[4
]}

Chen, Xiaoyuan ^{[2
]}

Nie, Zhihong ^{[1
]}

机构：

[1] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA

[2] Natl Inst Biomed Imaging & Bioengn, Lab Mol Imaging Nanomed LOMIN, NIH, Bethesda, MD 20892 USA

[3] Shanghai Jiao Tong Univ, Inst Micronano Sci & Technol, Shanghai 200240, Peoples R China

[4] Nanjing Univ, Coll Med, Sch Clin, Jinling Hosp, Nanjing 210000, Jiangsu, Peoples R China

[5] Xiamen Univ, Sch Publ Hlth, Ctr Mol Imaging & Translat Med, Xiamen 361005, Peoples R China

来源：

ACS NANO | 2013年 / 7卷 / 06期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

gold vesicles; plasmonic coupling effect; photoacoustic imaging; photothermal therapy; photodynamic therapy; synergistic therapy; PHOTODYNAMIC THERAPY; DRUG-DELIVERY; NANOPARTICLES; NANORODS; PORPHYRIN;

D O I：

10.1021/nn4011686

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A multifunctional theranostic platform based on photosensitizer-loaded plasmonic vesicular assemblies of gold nanoparticles (GNPs) is developed for effective cancer Imaging and treatment. The gold vesicles (GVs) composed of a monolayer of assembled GNPs show strong absorbance in the near-Infrared (NIR) range of 650-800 nm, as a result of the plasmonic coupling effect between neighboring GNPs in the vesicular membranes. The strong NIR absorption and the capability of encapsulating photosensitizer Ce6 in GVs enable trimodality NIR fluorescence/thermal/photoacoustic Imaging-guided synergistic photothermal/photodynamic therapy (PTT/PDT) with improved efficacy. The Ce6-loaded GVs (GV-Ce6) have the following characteristics: (i) high Ce6 loading efficiency (up to similar to 18.4 wt %; (ii) enhanced cellular uptake efficiency of Ce6; (iii) simultaneous trimodality NIR fluorescence/thermal/photoacoustic imaging; (iv) synergistic PTT/PDT treatment with improved efficacy using single wavelength continuous wave laser irradiation.

引用

页码：5320 / 5329

页数：10

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