Transcription factories, chromatin loops, and the dysregulation of gene expression in malignancy

被引：29

作者：

Deng, Binwei ^{[1
]}

Melnik, Svitlana ^{[1
]}

Cook, Peter R. ^{[1
]}

机构：

[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

来源：

SEMINARS IN CANCER BIOLOGY | 2013年 / 23卷 / 02期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

Chromatin loop; Enhancer; Factory; RNA polymerase; Silencer; Transcription; CHROMOSOME CONFORMATION CAPTURE; RNA-POLYMERASE; ORGANIZATION; NUCLEAR; DOMAINS; SITES; MODEL; DIFFERENTIATION; VISUALIZATION; DYNAMICS;

D O I：

10.1016/j.semcancer.2012.01.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pathologists recognize and classify cancers according to nuclear morphology, but there remains little scientific explanation of why malignant nuclei possess their characteristic features, or how those features are related to dysregulated function. This essay will discuss a basic structure-function axis that connects one central architectural motif in the nucleus-the chromatin loop-to the vital nuclear function of transcription. The loop is attached to a "transcription factory" through components of the transcription machinery (either polymerases or transcriptional activators/repressors), and the position of a gene within a loop determines how often that gene is transcribed. Then, dysregulated transcription is tightly coupled to alterations in structure, and vice versa. We also speculate on how the experimental approaches being used to analyze loops and factories might be applied to study the problems of tumour initiation and progression. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：65 / 71

页数：7

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