Vertical transmission of hepatitis B virus despite maternal lamivudine therapy

被引：71

作者：

Kazim, SN

Wakil, SM

Khan, LA

Hasnain, SE

Sarin, SK ^{[1
]}

机构：

[1] GB Pant Hosp, Dept Gastroenterol, New Delhi 110002, India

[2] Jamia Millia Islamia, Dept Biosci, New Delhi 110025, India

[3] Jamia Hamdard, Dept Toxicol & Med Elementol, New Delhi, India

[4] Natl Inst Immunol, Eukaryot Gene Express Lab, New Delhi 110067, India

[5] Ctr DNA Fingerprinting & Diagnost, Hyderabad, Andhra Pradesh, India

来源：

LANCET | 2002年 / 359卷 / 9316期

关键词：

D O I：

10.1016/S0140-6736(02)08425-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Lamivudine given during the last weeks of pregnancy in women with chronic hepatitis B has been reported to be safe. We report a case of chronic hepatitis B virus (HBV) infection in a newborn, despite suppression of HBV DNA to undetectable levels in the mother by prolonged lamivudine therapy. The newborn had raised alanine aminotransferase concentrations and was positive for HBV DNA at birth which persisted until 9 months of age, despite neonatal vaccination, treatment with hepatitis B immune globulin, and high concentrations of anti-HBs. On HBV DNA sequencing, complete sequence homology and a similar precore mutation was found in the mother and child, indicating vertical transmission. Lamivudine therapy might not prevent perinatal transmission of HBV infection in every newborn.

引用

页码：1488 / 1489

页数：2

共 5 条

[1]

AKOREA US, 1994, HEPATOLOGY, V19, P1366

[2] Ten-year neonatal hepatitis B vaccination program, the Netherlands, 1982-1992: protective efficacy and long-term immunogenicity [J].