The aggregate effects of multiple comorbid risk factors on cognition among HIV-infected individuals

被引：28
作者：
Patel, Sapna M. [1 ,2 ]
Thames, April D. [1 ,2 ]
Arbid, Natalie [2 ]
Panos, Stella E. [1 ,2 ]
Castellon, Steven [1 ,2 ]
Hinkin, Charles H. [1 ,2 ]
机构：
[1] Univ Calif Los Angeles, Los Angeles, CA 90095 USA
[2] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA
来源：
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY | 2013年 / 35卷 / 04期
关键词：
HIV; Neuropsychology; Comorbid risk factors; Aging; Cognition; HUMAN-IMMUNODEFICIENCY-VIRUS; HEPATITIS-C VIRUS; INTIMA-MEDIA THICKNESS; NEUROPSYCHOLOGICAL TEST-PERFORMANCE; ANTIRETROVIRAL THERAPY; MEDICATION ADHERENCE; DRUG-USE; METHAMPHETAMINE DEPENDENCE; NEUROCOGNITIVE DISORDERS; CARDIOVASCULAR-DISEASE;
D O I：
10.1080/13803395.2013.783000
中图分类号：
B849 [应用心理学];
学科分类号：
040203 ;
摘要：
This study developed and then cross-validated a novel weighting algorithm based on multiple comorbid risk factors (stimulant use, vascular disease, hepatitis C, HIV disease severity, cognitive reserve) to predict cognitive functioning among 366 HIV+ adults. The resultant risk severity score was used to differentially weight, as a function of age, the impact and magnitude of multiple risk factors on cognition. Among older adults (50 years) the risk severity index was differentially predictive of learning/memory and verbal fluency, whereas among younger adults it was linked to working memory and executive function. Cognitive reserve was found to be the most robust predictor of neurocognition.
引用
收藏
页码：421 / 434
页数：14
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