Reusable polymer-supported catalyst for the [3+2] Huisgen cycloaddition in automation protocols

被引：287

作者：

Girard, C

Önen, E

Aufort, M

Beauvière, S

Samson, E

Herscovici, J

机构：

[1] Ecole Natl Super Chim Paris, F-75005 Paris, France

[2] INSERM, U640, F-75006 Paris, France

[3] CNRS, UMR8151, F-75006 Paris, France

[4] Univ Paris 05, Fac Pharm, Unite Pharmacol Chim & Genet, F-75270 Paris, France

[5] CNRS, Chim Mol Paris Ctr, F-75005 Paris, France

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 08期

关键词：

D O I：

10.1021/ol060283l

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A polymer-supported catalyst for Huisgen's [3+2] cycloaddition reaction between azides and alkynes was prepared from copper(I) iodide and Amberlyst A-21. This catalyst was then used in an automated synthesis of 1,4-disubstituted 1,2,3-triazoles giving access to these products in good yields. The catalyst has shown good activity, stability, and recycling capabilities.

引用

页码：1689 / 1692

页数：4

共 19 条

[1] A microwave-assisted click chemistry synthesis of 1,4-disubstituted 1,2,3-triazoles via a copper(I)-catalyzed three-component reaction [J].