MicroRNA-146a acts as a metastasis suppressor in gastric cancer by targeting WASF2

被引：96

作者：

Yao, Qunyan ^{[1
]}

Cao, Zhongwei ^{[2
]}

Tu, Chuantao ^{[1
]}

Zhao, Yuan ^{[1
]}

Liu, Hongchun ^{[1
]}

Zhang, Shuncai ^{[1
]}

机构：

[1] Fudan Univ, Zhongshan Hosp, Dept Gastroenterol, Shanghai 200433, Peoples R China

[2] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Dept Gastroenterol, Shanghai 200030, Peoples R China

来源：

CANCER LETTERS | 2013年 / 335卷 / 01期

关键词：

MicroRNA; Gastric cancer; Metastasis; Target gene; WASF2; TUMOR-CELL INVASION; HOMOLOGOUS PROTEIN-2; EXPRESSION; MIR-146A; WAVE2; COEXPRESSION; MECHANISM; ROLES; MODES;

D O I：

10.1016/j.canlet.2013.02.031

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Previous studies have shown that miR-146a acts as either an oncogene or a tumor suppressor in various cancers. In this study, we investigated the role of miR-146a in gastric cancer cells and its potential target genes. The results showed that miR-146a expression correlated inversely with WASF2 protein expression in gastric cancer cell lines. Overexpression of miR-146a suppressed the migration and invasion of gastric cancer cells, and also the protein level of WASF2. WASF2 was shown to be a direct target gene of miR-146a by luciferase assays. Restoration of WASF2 promoted the migration and invasion of gastric cancer cells, similar to that mediated by miR-146a inhibition. This study has identified an onco-suppressive role of miR-146a in gastric cancer cells by its reduction of WASF2 expression. The newly identified miR-146a/WASF2 axis partially reveals the molecular mechanism underlying the migration and invasion of gastric cancer cells and represents a new potential therapeutic target for gastric cancer. (c) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：219 / 224

页数：6

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