An Efficient Method for the Selective Iodination of α,β-Unsaturated Ketones

被引：34

作者：

Wang, Zihua ^{[1
]}

Yin, Guodong ^{[1
]}

Qin, Jing ^{[1
]}

Gao, Meng ^{[1
]}

Cao, Liping ^{[1
]}

Wu, Anxin ^{[1
]}

机构：

[1] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2008年 / 22期

基金：

中国国家自然科学基金;

关键词：

iodination; alpha; beta-unsaturated ketones; beta-unsaturated alpha '-iodo ketones; self-sorting;

D O I：

10.1055/s-0028-1083200

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient approach to alpha,beta-unsaturated alpha'-iodo ketones directly from alpha,beta-unsaturated ketones by selective iodination at the alpha'-position, without effect on the double bond and the activated benzene ring, in the presence of copper(II) oxide/iodine is described. The present method has the advantages of high yields, short reaction times, inexpensive reagents, mild reaction conditions, ease of manipulation, and the formation of cleaner products.

引用

页码：3675 / 3681

页数：7

共 46 条

[41] STEREOCHEMICAL BEHAVIOR OF INTERMEDIARY COMPOUNDS IN THE AMINE-CATALYZED KNOEVENAGEL REACTION [J].