Maslinic Acid: A New Compound for the Treatment of Multiple Organ Diseases

被引：22
作者：
He, Yan [1 ]
Wang, Yi [1 ]
Yang, Kun [1 ]
Jiao, Jia [2 ]
Zhan, Hong [2 ]
Yang, Youjun [1 ]
Lv, De [3 ]
Li, Weihong [1 ]
Ding, Weijun [1 ]
机构：
[1] Chengdu Univ Tradit Chinese Med, Dept Fundamental Med, 1166 Liutai Ave, Chengdu 611137, Peoples R China
[2] Chengdu Univ Tradit Chinese Med, Dept Clin Med, 1166 Liutai Ave, Chengdu 611137, Peoples R China
[3] Chengdu Univ Tradit Chinese Med, Affiliated Hosp, Chengdu 611137, Peoples R China
来源：
MOLECULES | 2022年 / 27卷 / 24期
基金：
中国国家自然科学基金;
关键词：
Maslinic acid; extraction; purification; identification; biological activity; pharmacokinetics; treatment of multiple organ diseases; ACUTE KIDNEY INJURY; PERFORMANCE LIQUID-CHROMATOGRAPHY; INDUCED DIABETIC-RATS; FATTY LIVER-DISEASE; POMACE OLIVE OIL; OLEA-EUROPAEA; TRITERPENIC ACIDS; BIOACTIVE COMPOUND; OXIDATIVE STRESS; CANCER CELLS;
D O I：
10.3390/molecules27248732
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Maslinic acid (MA) is a pentacyclic triterpene acid, which exists in many plants, including olive, and is highly safe for human beings. In recent years, it has been reported that MA has anti-inflammatory, antioxidant, anti-tumor, hypoglycemic, neuroprotective and other biological activities. More and more experimental data has shown that MA has a good therapeutic effect on multiple organ diseases, indicating that it has great clinical application potential. In this paper, the extraction, purification, identification and analysis, biological activity, pharmacokinetics in vivo and molecular mechanism of MA in treating various organ diseases are reviewed. It is hoped to provide a new idea for MA to treat various organ diseases.
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页数：23
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