Single-cell resolution diagnosis of cancer cells by carbon nanotube electrical spectroscopy

被引：50

作者：

Abdolahad, M. ^{[1
]}

Janmaleki, M. ^{[2
]}

Taghinejad, M. ^{[1
]}

Taghnejad, H. ^{[1
]}

Salehi, F. ^{[1
]}

Mohajerzadeh, S. ^{[1
]}

机构：

[1] Univ Tehran, Sch Elect & Comp Engn, Nanoelect Ctr Excellence, Tehran, Iran

[2] Shahid Beheshti Univ Med Sci, Med Nanotechnol & Tissue Engn Res Ctr, Tehran, Iran

来源：

NANOSCALE | 2013年 / 5卷 / 08期

关键词：

MICROFLUIDIC DEVICE; DELIVERY-SYSTEM; QUANTUM DOTS; IMPEDANCE; MEMBRANE; NUCLEUS;

D O I：

10.1039/c3nr33430a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report the use of vertically aligned carbon nanotubes (VACNTs) as electrical endoscopes (biosensors) for cancer metastatic diagnosis at single-cell resolution. The device is based on direct signal extraction by means of vertically aligned conductive carbon nanotubes from a live cell membrane, which has been disrupted during carcinogenesis at its primary and progressive stages. The value of this electrical disruption depends on the cancer metastatic grade. In addition, the electrical resonance behavior of the cell, halted during cancer progression, could be monitored as a new cancer diagnostic profile. By taking a second derivative of the cell impedance with respect to applied frequency, we have arrived at a new spectroscopy tool for distinguishing cancerous stages of colon and breast carcinoma cells.

引用

页码：3421 / 3427

页数：7

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