Differential regulation of neurexin at glutamatergic and GABAergic synapses

被引：12
作者：
Pregno, Giulia [1 ]
Frola, Elena [1 ]
Graziano, Stefania [2 ,3 ]
Patrizi, Annarita [4 ]
Bussolino, Federico [2 ,3 ]
Arese, Marco [2 ,3 ]
Sassoe-Pognetto, Marco [1 ]
机构：
[1] Univ Turin, Dept Neurosci, I-10126 Turin, Italy
[2] Univ Turin, Dept Oncol Sci, Candiolo, Italy
[3] Univ Turin, Inst Canc Res & Treatment, Candiolo, Italy
[4] Harvard Univ, Childrens Hosp, Sch Med, FM Kirby Neurobiol Ctr, Boston, MA 02115 USA
来源：
FRONTIERS IN CELLULAR NEUROSCIENCE | 2013年 / 7卷
关键词：
neurexin; neuroligin; GABA(A) receptor; synaptic specificity; cerebellum; ALPHA-NEUREXINS; CEREBELLAR CORTEX; GLUR-DELTA-2; NEUROLIGINS; RECEPTOR; DELTA-2; GABA; SYNAPTOGENESIS; MECHANISMS; EXPRESSION;
D O I：
10.3389/fncel.2013.00035
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Neurexins (Nrxs) have emerged as potential determinants of synaptic specificity, but little is know about their localization at central synapses. Here we show that Nrxs have a remarkably selective localization at distinct types of glutamatergic synapses and we reveal an unexpected ontogenetic regulation of Nrx expression at GABAergic synapses. Our data indicate that synapses are specified by molecular interactions that involve both Nrx-dependent and Nrx-independent mechanisms. We propose that differences in the spatio-temporal profile of Nrx expression may contribute to specify the molecular identity of synapses.
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页数：7
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共 45 条
[1]   Refining the roles of GABAergic signaling during neural circuit formation [J].
Akerman, Colin J. ;
Cline, Hollis T. .
TRENDS IN NEUROSCIENCES, 2007, 30 (08) :382-389
[2]   The emerging role of synaptic cell-adhesion pathways in the pathogenesis of autism spectrum disorders [J].
Betancur, Catalina ;
Sakurai, Takeshi ;
Buxbaum, Joseph D. .
TRENDS IN NEUROSCIENCES, 2009, 32 (07) :402-412
[3]   The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions [J].
Bottos, Alessia ;
Destro, Erika ;
Rissone, Alberto ;
Graziano, Stefania ;
Cordara, Gabriele ;
Assenzio, Barbara ;
Cera, Maria Rosaria ;
Mascia, Luciana ;
Bussolino, Federico ;
Arese, Marco .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (49) :20782-20787
[4]   A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to α- and β-neurexins [J].
Boucard, AA ;
Chubykin, AA ;
Comoletti, D ;
Taylor, P ;
Südhof, TC .
NEURON, 2005, 48 (02) :229-236
[5]   Quantitative Organization of GABAergic Synapses in the Molecular Layer of the Mouse Cerebellar Cortex [J].
Briatore, Federica ;
Patrizi, Annarita ;
Viltono, Laura ;
Sassoe-Pognetto, Marco ;
Wulff, Peer .
PLOS ONE, 2010, 5 (08)
[6]   AXONAL COMPETITION IN THE SYNAPTIC WIRING OF THE CEREBELLAR CORTEX DURING DEVELOPMENT AND IN THE MATURE CEREBELLUM [J].
Cesa, R. ;
Strata, P. .
NEUROSCIENCE, 2009, 162 (03) :624-632
[7]   Alternative splicing controls selective trans-synaptic interactions of the neuroligin-neurexin complex [J].
Chih, Ben ;
Gollan, Leora ;
Scheiffele, Peter .
NEURON, 2006, 51 (02) :171-178
[8]   Neurexin-neuroligin signaling in synapse development [J].
Craig, Ann Marie ;
Kang, Yunhee .
CURRENT OPINION IN NEUROBIOLOGY, 2007, 17 (01) :43-52
[9]   Neurexin mediates the assembly of presynaptic terminals [J].
Dean, C ;
Scholl, FG ;
Choih, J ;
DeMaria, S ;
Berger, J ;
Isacoff, E ;
Scheiffele, P .
NATURE NEUROSCIENCE, 2003, 6 (07) :708-716
[10]   The expression of vesicular glutamate transporters defines two classes of excitatory synapse [J].
Fremeau, RT ;
Troyer, MD ;
Pahner, I ;
Nygaard, GO ;
Tran, CH ;
Reimer, RJ ;
Bellocchio, EE ;
Fortin, D ;
Storm-Mathisen, J ;
Edwards, RH .
NEURON, 2001, 31 (02) :247-260
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