A Prospective, Randomized, Placebo-Controlled Study to Identify Biomarkers Associated with Active Treatment in Psoriatic Arthritis: Effects of Adalimumab Treatment on Lesional and Nonlesional Skin

被引：12
作者：
de Groot, Marjan [1 ]
Picavet, Daisy I. [1 ]
van Kuijk, Arno W. R. [2 ]
Tak, Paul P. [2 ]
Bos, Jan D. [1 ]
de Rie, Menno A. [1 ]
Teunissen, Marcel B. M. [1 ]
机构：
[1] Univ Amsterdam, Acad Med Ctr, Dept Dermatol, NL-1105 AZ Amsterdam, Netherlands
[2] Univ Amsterdam, Acad Med Ctr, Dept Clin Immunol & Rheumatol, NL-1105 AZ Amsterdam, Netherlands
来源：
DERMATOLOGY | 2012年 / 225卷 / 04期
关键词：
Adalimumab; Psoriasis; Psoriatic arthritis; Biomarkers; Innate immunity; T-CELL SUBSETS; ANTIMICROBIAL PROTEINS; ATOPIC-DERMATITIS; CLINICAL-RESPONSE; ELASTASE ACTIVITY; SYNOVIAL TISSUE; DOUBLE-BLIND; PHASE-III; KERATINOCYTES; ACTIVATION;
D O I：
10.1159/000343290
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Background: There is a need for biomarkers to screen the effectiveness of (novel) therapeutic agents for psoriasis at an early stage. Objective: We aimed to determine which of the changes in psoriatic skin correlates best with clinical improvement 4 weeks after effective adalimumab therapy. Methods: Twenty-two psoriatic arthritis patients were randomized to receive adalimumab or placebo. T cell numbers and markers of innate immunity were estimated in lesional and nonlesional skin biopsies at baseline and after 4 weeks of treatment. Results: CD161+ and elastase+ dermal cells in lesional skin were significantly reduced upon 4 weeks of successful adalimumab treatment compared with placebo. Conclusion: Early improvement of psoriasis lesions during adalimumab therapy is associated with a marked reduction of infiltrated dermal CD161+ T cells and elastase+ neutrophils, suggesting that these parameters could be used as biomarkers to monitor early changes after active treatment in small proof-of-concept studies of short duration. Copyright (c) 2012 S. Karger AG, Basel
引用
收藏
页码：298 / 303
页数：6
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